Results 131 to 140 of about 4,919,522 (294)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Adherence to oral anticoagulant therapy in secondary stroke prevention – impact of the novel oral anticoagulants

, 2015
Sebastian Luger,1 Carina Hohmann,2 Daniela Niemann,1 Peter Kraft,3 Ignaz Gunreben,3 Tobias Neumann-Haefelin,2 Christoph Kleinschnitz,3 Helmuth Steinmetz,1 Christian Foerch,1 Waltraud Pfeilschifter1 1Department of Neurology, University Hospital Frankfurt,
Pfeilschifter W, Kleinschnitz C, Neumann-Haefelin T, Steinmetz H, Luger S, Niemann D, Kraft P, Foerch C, Gunreben I, Hohmann C   +9 more
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Primary and Secondary Prevention of Strokes

Медицинский вестник Юга России, 2012
We have made an attempt to systematize risk factors of primary and repeated ischemic strokes development. The divisions of the corrected and not corrected have been introduced in basis of systematization.
N. A. Fomina-Chertousova, K. A. Bondarenko   +1 more
doaj  

New directions in sexual assault prevention

, 2003
The central question that faces all of us who are committed to non-violence is how can we prevent sexual assault. This is a question that has been a concern of feminist politics for over a century and more recently for the last three decades.
Carmody, Moira
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Secondary prevention of stroke [PDF]

Australian and New Zealand Journal of Medicine, 1995
openaire   +2 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Secondary cardiovascular prevention: cardioprotective pharmaceutical therapy

Кардиоваскулярная терапия и профилактика, 2011
.
article Editorial
doaj  

Science of optimizing HIV prevention

This session of Grand Rounds will explore a High-Impact Prevention approach to prevent HIV in the United States. Because HIV incidence is stable and effective treatment exists to prevent illness and death, a growing number of persons--over 1.1 million ...
Centers for Disease Control and Prevention (U.S.) Office of the Associate Director for Communication.
core