Results 51 to 60 of about 26,876 (262)

MĂSURI DE PREVENIRE CARE URMĂRESC REDUCEREA CERERII DE DROGURI ŞI A CONSUMULUI ILICIT DE DROGURI

Studia Universitatis Moldaviae: Stiinte Sociale, 2017
Problematica drogurilor este şi va fi în permanenţă una dintre temele dominante ale vieţii sociopolitice nu doar din Republica Moldova, ci şi din întreaga lume, în dificila încercare de a găsi răspunsuri la multiplele şi complexele probleme legate de ...
Angela MIRON
doaj  

Prevention 1st by state mandate – Health promotion as an overarching educational goal and teaching principle in primary school curricula: A comparison between Austria, Germany and Switzerland

Current Issues in Sport Science
Introduction & Purpose Health is a basic prerequisite in leading a fulfilled life; thus, it is one of the major topics of our time. In line with the United Nations Sustainable Development Goals (UN SDG’s), especially Goals #3 “Good Health and Well ...
Katharina C. Wirnitzer, Isabella Troppe, Derrick R. Tanous   +2 more
doaj   +1 more source

Workaholism – Indications for diagnosis and review of interventions

Medycyna Pracy, 2015
Due to numerous psychological and health costs, the issue of workaholism requires taking appropriate actions by relevant specialists, including occupational medicine services.
Diana Malinowska, Sabina Staszczyk, Aleksandra Tokarz   +2 more
doaj   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Práticas de autocuidado em hanseníase: face, mãos e pés

Revista Gaúcha de Enfermagem, 2018
Resumo OBJETIVO Analisar as práticas de autocuidado em face, mãos e pés realizadas por pessoas atingidas pela hanseníase. METODOLOGIA Estudo qualitativo, realizado em unidades de referência para hanseníase em Pernambuco, entre maio de 2014 e abril de ...
Marize Conceição Ventin Lima, Fernanda Ribeiro Barbosa, Danielle Christine Moura dos Santos, Raphaela Delmondes do Nascimento, Stephanie Steremberg Pires D’Azevedo   +4 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

The impact of demographic factors on the level of knowledge about primary and secondary prevention of cervical cancer among patients in Lublin voivodeship

Family Medicine & Primary Care Review, 2016
Background. Cervical cancer (CC) is among the most-commonly detected cancers affecting women worldwide. The primary means of preventing CC is the Human Papillomavirus (HPV) vaccine.
Anna Puzio, Krzysztof Kułak, Małgorzata Repa, Joanna Ruszczyk, Katarzyna Skórzyńska-Dziduszko   +4 more
doaj   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source