Results 71 to 80 of about 26,876 (262)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Primary and Secondary Prevention of Obesity
Journal of Education, Health and SportIntroduction and purpose: Obesity is a persistent and recurring chronic condition marked by an excessive accumulation of body fat, which can deteriorate health, heighten the risk of complications, and shorten life expectancy.This review provides a ...
Aleksandra Kiełczewska +2 more
doaj +1 more source
Cancer Biology & Medicine, 2018 Objective: Extranodal extension in cervical lymph nodes is an important risk factor for the progression and prognosis of papillary thyroid cancer. The purpose of this study was to identify the common and characteristic preoperative ultrasonography ...
Jiali Mu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction [PDF]
, 1974 P C Elwood +7 more
openalex +1 more source
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Primary and secondary prevention
Medicine, 2010 Abstract The incidence of cardiovascular disease is determined by a complex interaction of risk factors acting over the life-course. This issue can be addressed through primary and secondary prevention. Cardiovascular disease is multifactorial in origin, and a number of potentially modifiable risk factors interplay to create the phenotype susceptible.
Ashley Nisbet, Adrian J B Brady
openaire +2 more sources
Secondary prevention. The utilization of public health nurses as agents of behavioral change in the community. [PDF]
, 1975 Katie Barnes
openalex +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source