Results 51 to 60 of about 12,303,796 (305)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Communicative potential of the library: experience of Bibliofest-2025 as part of the cultural mission of the school

Управление культурой
In today’s educational environment, the library has evolved from a simple repository of books into a dynamic communication platform that facilitates interaction, collaboration, and cultural exchange.
Dina M. Popovich, Yana A. Kravchuk
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Technical and economic efficiency of processing acidic wastewater from the oil and fat industry into necessary agricultural products [PDF]

E3S Web of Conferences
In this artist the economic efficiency of organizing the production of crude fatty acids in the fat and oil industry of Uzbekistan is presented.
Sotimboev Ilgizarbek, Baltaev Umidbek, Shamuratov Sanjarbek, Shamsiddin Ruzimov, Alimov Umarbek, Saporboyev Mirzabek   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Present scenario in respect of House-Sparrows’ depleting trends and conservation efforts in and around Kurukshetra, Haryana, India

Environment Conservation Journal, 2018
The present research work was carried out during 2003 to 2016 to aim the scenario of depleting trends and conservation efforts of House Sparrow in and around Kurukshetra district in Haryana province in India.
Tirshem Kumar Kaushik , Rohtash Chand Gupta   +1 more
doaj   +1 more source

The Role of the On-Line Multi-Media Library "Eco-School" in Extracurricular Activities of Students

Развитие образования, 2020
The experience of the urban secondary school on the development and implementation of its own model of the on-line multi-media library of environmental orientation as one of the clusters of multifunctional school information and library center is ...
Olga M. Truneva, Lyudmila V. Munkoeva, Irina V. Rubtsova   +2 more
doaj   +1 more source