Results 61 to 70 of about 1,997,381 (315)

Questioning in the Secondary School

Biblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 planta; 28014 Madrid; Tel.
Wragg, E.C., Brown, G.
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Communicative potential of the library: experience of Bibliofest-2025 as part of the cultural mission of the school

Управление культурой
In today’s educational environment, the library has evolved from a simple repository of books into a dynamic communication platform that facilitates interaction, collaboration, and cultural exchange.
Dina M. Popovich, Yana A. Kravchuk
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Technical and economic efficiency of processing acidic wastewater from the oil and fat industry into necessary agricultural products [PDF]

E3S Web of Conferences
In this artist the economic efficiency of organizing the production of crude fatty acids in the fat and oil industry of Uzbekistan is presented.
Sotimboev Ilgizarbek, Baltaev Umidbek, Shamuratov Sanjarbek, Shamsiddin Ruzimov, Alimov Umarbek, Saporboyev Mirzabek   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Present scenario in respect of House-Sparrows’ depleting trends and conservation efforts in and around Kurukshetra, Haryana, India

Environment Conservation Journal, 2018
The present research work was carried out during 2003 to 2016 to aim the scenario of depleting trends and conservation efforts of House Sparrow in and around Kurukshetra district in Haryana province in India.
Tirshem Kumar Kaushik , Rohtash Chand Gupta   +1 more
doaj   +1 more source

The Role of the On-Line Multi-Media Library "Eco-School" in Extracurricular Activities of Students

Развитие образования, 2020
The experience of the urban secondary school on the development and implementation of its own model of the on-line multi-media library of environmental orientation as one of the clusters of multifunctional school information and library center is ...
Olga M. Truneva, Lyudmila V. Munkoeva, Irina V. Rubtsova   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source