Results 51 to 60 of about 1,592,250 (363)

Digital libraries at home and abroad for the needs of instruction in the school library

open access: yesKnjižnica, 2001
The authors describe some cases and indicate some possible uses of digital libraries (some of them can also be examples of their construction) for educational purposes, at home and abroad.
Zdenka Verlič
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

the prevalence of dental crossbite in students of secondary schools of Kerman city in 1994-95 [PDF]

open access: yesJournal of Kerman University of Medical Sciences, 1997
crossbite is a term used to indicate an abnormal buccolingual (labiolingual) relationship of the teeth and can results in unfavorable effects when it is left untreated.the last growth spurt which occurs about the age of 11-12 years in females and 14-15 ...
B.A Ramazanzadeh, K Laghaei
doaj  

Problem of study in secondary schools [PDF]

open access: yes, 1925
Thesis (Ed.M.)--Boston ...
Martin, Catherine J
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Informal violence in secondary schools [PDF]

open access: yesSinteze, 2016
Various forms of formal and informal violence can be found in secondary schools. Situations in which only one form of violence is present are rare; informal violence often preceds various forms of formal violence and the other way round.
Mikanović Brane R., Maran Marijana M.
doaj  

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