E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Perception of Menarche among Secondary Schools Students in Baghdad City
Kufa Journal for Nursing Sciences, 2014 Objectives: The aim of this study is to assess menarche impression and perception among secondary schools students Methodology: Cross-sectional study was conducted to select a sample purposely of fifty-five students in the first class of intermediate ...
Suhad H. Khairi
doaj +1 more source
S3 Pupils' Career Aspirations and Views on Language Learning [PDF]
, 2007 In May 2005, the Scottish Centre for Language Teaching and Research (SCILT) undertook a government-funded nationwide survey of approximately 1500 pupils in the S3 cohort of Scottish secondary schools.
Doughty, Hannah +2 more
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Practical work : Its effectiveness in primary and secondary schools in England [PDF]
, 2012 We report here on the first of two evaluations of a national project (Getting Practical: Improving Practical Work in Science – IPWiS) designed to improve the effectiveness of practical work in both primary and secondary schools in England.
Abrahams +58 more
core +3 more sources
Reflections on the Implementation of Competence Based Curriculum in Tanzanian Secondary Schools.
, 2015 This study investigated issues surrounding the implementation of competence based curriculum in Tanzanian secondary schools. The specific objectives of the study were to examine the teachers’ understanding of the objectives of competence based curriculum;
S. Komba, Marcus Mwandanji
semanticscholar +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Bullying in school children: How much do teachers know?
Journal of Family Medicine and Primary Care, 2019 Context: Bullying is an emerging serious problem in schools worldwide resulting in physical and mental health problems in victimized children. Teachers play a critical role in identifying the acts of bullying, assisting the children who are victimized ...
Nida I Shamsi +2 more
doaj +1 more source
Transition plans and grants: an evaluation of the impact of transition plans and grant on primary and secondary school partnerships at key stage 2 and key stage 3 [PDF]
, 2010 "This report for the Welsh Assembly Government evaluates how well local authorities and school clusters work together to improve continuity and progression in learning for pupils moving from key stage 2 in primary schools to key stage 3 in secondary ...
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CLASSROOM INTERACTION STRATEGIES EMPLOYED BY ENGLISH TEACHERS AT LOWER SECONDARY SCHOOLS
, 2015 This article reports a study on teachers’ use of interaction strategies in English Language Teaching (ELT) in lower secondary level of education. The study involved eighteen teachers from Lower Secondary Schools in Malang, East Java.
N. Suryati
semanticscholar +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source