Results 131 to 140 of about 1,704,223 (314)

Protein secondary structure prediction by artificial neural networks

, 2010
碩士蛋白質的組成控制著它的功能，而人體裡面有數百甚至數千個蛋白質的存在，因此我們會想要去知道蛋白質個別的功用及它們之間彼此是如何互動的，而這個領域被稱作蛋白質體學，它的目的主要是在調查在生物裡面的蛋白質的功能為何。 蛋白質的功能是決定於它的架構，目前X光結晶繞射照影(X-ray Crystallography) 與核磁共振(Nuclear Magnetic Resonance)(NMR)都能夠視覺化蛋白質的三維架構。然而它們是耗費時間且昂貴的，而所耗費的時間長達數週到數個月，另外也有解析上的問題 ...
張建蒼; Chang, Jian-tsang
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Design and commission of an experimental test rig to apply a full-scale pressure load on composite sandwich panels representative of aircraft secondary structure

, 2010
This paper describes the design of a test rig, which is used to apply a representative pressure load to a full-scale composite sandwich secondary aircraft structure.
Crump, D.A., Savage, J., Dulieu-Barton, J.M.   +2 more
core   +1 more source

Electrical Fields in the Processing of Protein-Based Foods

Foods
Electric field-based technologies offer interesting perspectives which include controlled heat dissipation (via the ohmic heating effect) and the influence of electrical variables (e.g., electroporation). These factors collectively provide an opportunity
Ricardo N. Pereira, Rui Rodrigues, Zita Avelar, Ana Catarina Leite, Rita Leal, Ricardo S. Pereira, António Vicente   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Calibration and standardisation of synchrotron radiation circular dichroism and conventional circular dichroism spectrophotometers [PDF]

, 2003
Synchrotron radiation circular dichroism (SRCD) is an emerging technique in structural biology with particular value in protein secondary structure analyses since it permits the collection of data down to much lower wavelengths than conventional ...
Wien, Frank, Wallace, Bonnie Ann, Rodger, Alison, Lees, Jonathan G., Miles, Andrew J.   +4 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The tree alignment model : algorithms, implementations and applications for the analysis of RNA secondary structures

, 2005
Höchsmann M. The tree alignment model : algorithms, implementations and applications for the analysis of RNA secondary structures. Bielefeld (Germany): Bielefeld University; 2005.Phylogenetic analysis of nucleotide sequences and amino acid sequences has ...
Höchsmann, Matthias
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Debt concentration and secondary market prices [PDF]

Using a model that distinguishes between large money center banks and smaller regional banks, this paper shows that the percentage of a country's debt held by the large banks affects the secondary market price of that country's debt: the higher the ...
Fernandez, Raquel, Ozler, Sule
core