Results 111 to 120 of about 1,704,223 (314)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K.

, 2013
PMCID: PMC3591419This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
Chad M Rienstra, Julia M. George (386756), Rikardsen, LK, Shin W Lee, Lars K. Rikardsen (386754), Gemma Comellas, Luisel R. Lemkau, Shin W. Lee (386753), Lars K Rikardsen, Rienstra Chad M., Lee, SW, Lee Shin W., Woods, WS, Lemkau, LR, Julia M. George, Luisel R. Lemkau (386752), Comellas, G, George, JM, Rikardsen Lars K., Wendy S. Woods (386755), Wendy S Woods, Woods Wendy S., Chad M. Rienstra, George Julia M., Shin W. Lee, Rienstra, CM, Lars K. Rikardsen, Chad M. Rienstra (386757), Luisel R Lemkau, Julia M George, Wendy S. Woods, Lemkau Luisel R., Comellas Gemma, Gemma Comellas (371865)   +33 more
core   +1 more source

Combinatorics of RNA secondary structures

Discrete Applied Mathematics, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ivo L. Hofacker, Peter Schuster 0002, Peter F. Stadler   +2 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Rapid Quantification of Protein Secondary Structure Composition from a Single Unassigned 1D 13C NMR Spectrum

The function of a protein is predicated upon its three dimensional fold. Representing its complex structure as a series of repeating secondary structural elements is one of the most useful ways by which we study, characterize, and visualize a protein ...
Haote, Li, Victor, Batista, Kurt, Zilm, Marcus, Tuttle   +3 more
core   +1 more source

Secondary transfer effects of intergroup contact via social identity complexity.

, 2014
Secondary transfer effects (STEs) of intergroup contact refer to the generalization of contact effects from a primary encountered outgroup to attitudes towards secondary outgroups (Pettigrew, 2009). Using two large, cross-sectional data sets from Germany
Hewstone, Miles, Hewstone, M, Tausch, Nicole, Tausch, N, Schmid, Katharina   +4 more
core   +1 more source

Enumerative aspects of secondary structures

Discrete Mathematics, 2004
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Došlić, Tomislav, Veljan, Darko, Svrtan, Dragutin   +2 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Protein secondary structure prediction methods based on RBF neural networks

, 2004
To solve the complicated non-linear mode-sorting problem of protein secondary structure prediction, the chapter proposed a new method based on radial basis function neural networks and learning from evolution.
Jing N, Zhou CG, Xia B, Wang Y
core  

Distribution and Evolutionary History of the Mobile Genetic Element s2m in Coronaviruses

Diseases, 2016
The mobile genetic element s2m has been described in several families of single-stranded RNA viruses. The function remains elusive, but an increasing number of s2m-containing sequences are being deposited in publicly available databases.
Torstein Tengs, Christine M. Jonassen
doaj   +1 more source