Results 91 to 100 of about 4,481,762 (297)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A Simple Comparison between Specific Protein Secondary Structure Prediction Tools

Tropical Agricultural Research, 2012
A comparative evaluation of five widely used protein secondary structure prediction programs available in World Wide Web was carried out. Secondary structure data of ten proteins containing 190 secondary structure motifs were collected from Protein Data ...
TJ Koswatta, P Samaraweera, VA Sumanasinghe   +2 more
doaj   +1 more source

Testing the helix model for protein folding on four simple proteins

, 1997
We test a simplified, local version of the helix model on two synthetic and two natural proteins, to study its efficiency in predicting the native secondary structure.
Bruscolini, Pierpaolo
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Ground state and glass transition of the RNA secondary structure

, 2006
RNA molecules form a sequence-specific self-pairing pattern at low temperatures. We analyze this problem using a random pairing energy model as well as a random sequence model that includes a base stacking energy in favor of helix propagation.
Bundschuh, Bundschuh, Carpentier, Dill, Gennes, Halpin-Healy, Hartmann, Higgs, Hwa, Hwa, Isaacs, Jr, Jr, Karlin, Krzakala, L.-H. Tang, Lässig, Marinari, Mukhopadhyay, Mézard, Nussinov, Onuchic, Pagnani, S. Hui, Schueler-Furman, Shakhnovich, Snow, Tang, Tang, Yu, Zeng, Zuker   +31 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Implication des peptides de fusion des glycoprotéines de fusion virales de classe I dans la fusion membranaire [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2007
The implication of fusion peptides of class I viral fusion glycoproteins in the membrane fusion. Viral infection involves fusion between the viral envelope and the target cell plasmic membrane.
Brasseur R., Charloteaux B., Lins L., Lorin A.   +3 more
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Signatures of Secondary Collisionless Magnetic Reconnection Driven by Kink Instability of a Flux Rope

, 2014
The kinetic features of secondary magnetic reconnection in a single flux rope undergoing internal kink instability are studied by means of three-dimensional Particle-in-Cell simulations.
Delzanno, G. L., Goldman, M. V., Henri, P., Intrator, T., Lapenta, G., Laure, E., Markidis, S., Newman, D. L.   +7 more
core   +3 more sources