Results 81 to 90 of about 10,953,173 (309)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Rapid Quantification of Protein Secondary Structure Composition from a Single Unassigned 1D 13C NMR Spectrum [PDF]
The function of a protein is predicated upon its three dimensional fold. Representing its complex structure as a series of repeating secondary structural elements is one of the most useful ways by which we study, characterize, and visualize a protein ...
Haote, Li +3 more
core +2 more sources
Relevance of G-quadruplex structures to pharmacogenetics
Frontiers in Pharmacology, 2014 G-quadruplexes are non-canonical secondary structures formed within nucleic acids that are involved in modulating cellular processes such as replication, gene regulation, recombination and epigenetics.
Martin A Kennedy, Simone Lynette Cree
doaj +1 more source
Amplification of Filia, a Bovine GC Rich Gene, by Optimization of Primer Design [PDF]
مجله بیوتکنولوژی کشاورزی, 2015 Filia is a maternal effect gene, disorder in which causes decreased fertility in mouse and abortion in human. Bovine Filia transcript is predicted in NCBI database. Nucleotide analysis shows that it has a higher GC content in comparison with its mouse or
Azadeh Zahmat Kesh +4 more
doaj +1 more source
Combinatorics of RNA secondary structures
Discrete Applied Mathematics, 1998 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ivo L. Hofacker +2 more
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A Simple Comparison between Specific Protein Secondary Structure Prediction Tools
Tropical Agricultural Research, 2012 A comparative evaluation of five widely used protein secondary structure prediction programs available in World Wide Web was carried out. Secondary structure data of ten proteins containing 190 secondary structure motifs were collected from Protein Data ...
TJ Koswatta +2 more
doaj +1 more source
, 2014 Citation: 'secondary structure' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.S05530 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source