Results 71 to 80 of about 18,178,221 (305)

Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences

Nature Communications, 2020
Novel antibiotics are urgently needed to address the looming global crisis of antibiotic resistance. Historically, the primary source of clinically used antibiotics has been microbial secondary metabolism.
M. Skinnider, Chad W. Johnston, Mathusan Gunabalasingam, Nishanth J. Merwin, Agata M Kieliszek, Robyn J. MacLellan, Haoxin Li, Michael R. M. Ranieri, Andrew L. H. Webster, My P. T. Cao, Annabelle Pfeifle, Norman Spencer, Q. H. To, Dan Wallace, C. Dejong, N. Magarvey   +15 more
semanticscholar   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

2Struc: the secondary structure server [PDF]

Bioinformatics, 2010
Abstract Summary: The defined secondary structure of proteins method is often considered the gold standard for assignment of secondary structure from three-dimensional coordinates. However, there are alternative methods. ‘2Struc: The Secondary Structure Server’ has been created as a single point of access for eight different secondary ...
D. P. Klose, B. A. Wallace, Robert W. Janes   +2 more
openaire   +2 more sources

Inpatient Exposure, Confidence, and Knowledge in Pediatric Hematology/Oncology: Evaluating General Pediatric Residents During 2025 ACGME Curriculum Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background General pediatricians often evaluate hematologic and oncologic presentations before subspecialty consultation, yet the 2025 Accreditation Council for Graduate Medical Education (ACGME) pediatric requirements reduce inpatient pediatric hematology/oncology (PHO) time, raising questions about resident readiness.
Colburn Yu, Rohini Jain
wiley   +1 more source

Modify possibilities of the secondary structures prediction method

Lietuvos Matematikos Rinkinys, 2003
It was analyzed dependence of the average accuracy of secondary protein structure prediction on various GOR algorithm modifications. In essence new modification has expanded informational parameter set by taking into account secondary structure of ...
Alvydas Špokas, Albertas Timinskas
doaj   +3 more sources

Conserved Secondary Structures in Viral mRNAs

Viruses, 2019
RNA secondary structure in untranslated and protein coding regions has been shown to play an important role in regulatory processes and the viral replication cycle.
Michael Kiening, Roman Ochsenreiter, Hans-Jörg Hellinger, Thomas Rattei, Ivo Hofacker, Dmitrij Frishman   +5 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

The effect of Arginine, Lysine and Histidine in the myosin secondary structure by circular dichroism and Raman spectroscopy

CyTA - Journal of Food, 2019
Amino acids containing L-Arginine (Arg), L-Lysine (Lys) and L-Histidine (His) are recognized to increase the solubility of myosin at low ionic strength, but there is a difference in the researchers’ views on their effects on the secondary structure of ...
Tong Shi, Li Yuan, Jianlou Mu, Ruichang Gao   +3 more
doaj   +1 more source

Aza-Amino Acids Disrupt β-Sheet Secondary Structures

Molecules, 2019
Cα to N substitution in aza-amino acids imposes local conformational constraints, changes in hydrogen bonding properties, and leads to adaptive chirality at the nitrogen atom. These properties can be exploited in mimicry and stabilization of peptide
Michael A. McMechen, Evan L. Willis, Preston C. Gourville, Caroline Proulx   +3 more
doaj   +1 more source

Dynamics of translation by single ribosomes through mRNA secondary structures

Nature Structural &Molecular Biology, 2013
During protein synthesis, the ribosome translates nucleotide triplets in single-stranded mRNA into polypeptide sequences. Strong downstream mRNA secondary structures, which must be unfolded for translation, can slow or even halt protein synthesis.
Chunlai Chen, Haibo Zhang, S. Broitman, Michael Reiche, Ian Farrell, B. Cooperman, Y. Goldman   +6 more
semanticscholar   +1 more source