Results 81 to 90 of about 7,219,249 (302)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The DNA secondary structures at telomeres and genome instability
Cell & Bioscience, 2020 Telomeric DNA are TTAGGG tandem repeats, which are susceptible for oxidative DNA damage and hotspot regions for formation of DNA secondary structures such as t-loop, D-loop, G-quadruplexes (G4), and R-loop.
Jun Tan, Li Lan
doaj +1 more source
Spaces of RNA Secondary Structures
Advances in Mathematics, 1993 The primary goal of the authors is to contribute to investigations of the secondary structure of RNA. The starting point are bond pictures that give rise to partially ordered sets of macromolecules. For such posets corresponding to classes of ``arbitrary'' and ``binary'' macromolecules (the latter being motivated by the study of secondary structures of
Penner, R.C., Waterman, M.S.
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Capturing alternative secondary structures of RNA by decomposition of base-pairing probabilities
BMC Bioinformatics, 2018 Background It is known that functional RNAs often switch their functions by forming different secondary structures. Popular tools for RNA secondary structures prediction, however, predict the single ‘best’ structures, and do not produce alternative ...
Taichi Hagio +4 more
doaj +1 more source
Papers on predicative constructions : Proceedings of the workshop on secundary predication, October 16-17, 2000, Berlin [PDF]
, 2001 This volume presents a collection of papers touching on various issues concerning the syntax and semantics of predicative constructions. A hot topic in the study of predicative copula constructions, with direct implications for the treatment of he (how ...
Strigin, Anatolij +3 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Effect of oil contents on gluten network during the extrusion processing
Czech Journal of Food Sciences, 2019 To investigate a comparative evaluation of the gluten polymerization properties at different oil contents during the extrusion processing, the electrophoretic profiles of the gluten, free sulfhydryl (SH) compounds, the secondary structure of gluten ...
Feng Jia +6 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Secondary predication in Russian [PDF]
, 2001 The paper makes two contributions to semantic typology of secondary predicates. It provides an explanation of the fact that Russian has no resultative secondary predicates, relating this explanation to the interpretation of secondary predicates in ...
Demjjanow, Assinja, Strigin, Anatoli
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