Results 101 to 110 of about 7,219,249 (302)

Strategies for measuring evolutionary conservation of RNA secondary structures

BMC Bioinformatics, 2008
Background Evolutionary conservation of RNA secondary structure is a typical feature of many functional non-coding RNAs. Since almost all of the available methods used for prediction and annotation of non-coding RNA genes rely on this evolutionary ...
Hofacker Ivo L, Bernhart Stephan H, Gruber Andreas R, Washietl Stefan   +3 more
doaj   +1 more source

Enumerative aspects of secondary structures

Discrete Mathematics, 2004
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Došlić, Tomislav, Veljan, Darko, Svrtan, Dragutin   +2 more
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Peptide‐Based Assemblies for Supercapacitor Applications

Small Science
The increased focus on green energy storage devices and the related rapid advancement in biomedical technologies makes the investigation of biocompatible integrated systems with medical relevance increasingly important.
Sohini Chakraborty, Kamal el Battioui, Tamás Beke-Somfai   +2 more
doaj   +1 more source

COOLAIR Antisense RNAs Form Evolutionarily Conserved Elaborate Secondary Structures

Cell Reports, 2016
There is considerable debate about the functionality of long non-coding RNAs (lncRNAs). Lack of sequence conservation has been used to argue against functional relevance. We investigated antisense lncRNAs, called COOLAIR, at the A. thaliana FLC locus and
Emily J. Hawkes, Scott P. Hennelly, Irina V. Novikova, Judith A. Irwin, Caroline Dean, Karissa Y. Sanbonmatsu   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Evaluating the response modification factor (R) for reinforced concrete and steel structures equipped with TADAS devices designed for high seismic hazard in Colombia

Colombia is a country with high seismic activity due to its location at the convergence of the Nazca and South American tectonic plates, making structural safety a key priority in the design, construction, and retrofit of buildings. Currently, one of the
Villalba-Morales J.D, Molina-Herrera M, Arroyo O., Caballero-Castro L.F, Cano-Castaño H.A   +4 more
core   +1 more source

The structures of depictive and resultative constructions in chinese [PDF]

, 2013
In this paper I firstly argue that secondary predicates are complement of v, and v is overtly realized by Merge or Move in secondary predication in Chinese.
Zhang, Niina
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source