Results 111 to 120 of about 18,178,221 (305)

Evolution of conserved secondary structures and their function in transcriptional regulation networks

BMC Genomics, 2008
Background Many conserved secondary structures have been identified within conserved elements in the human genome, but only a small fraction of them are known to be functional RNAs.
Irwin David M, Xie Hai-Bing, Zhang Ya-Ping   +2 more
doaj   +1 more source

Combinatorics of RNA secondary structures

Discrete Applied Mathematics, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ivo L. Hofacker, Peter Schuster 0002, Peter F. Stadler   +2 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Enumerative aspects of secondary structures

Discrete Mathematics, 2004
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Došlić, Tomislav, Veljan, Darko, Svrtan, Dragutin   +2 more
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Peptide‐Based Assemblies for Supercapacitor Applications

Small Science
The increased focus on green energy storage devices and the related rapid advancement in biomedical technologies makes the investigation of biocompatible integrated systems with medical relevance increasingly important.
Sohini Chakraborty, Kamal el Battioui, Tamás Beke-Somfai   +2 more
doaj   +1 more source

Identification of consensus RNA secondary structures using suffix arrays

BMC Bioinformatics, 2006
Background The identification of a consensus RNA motif often consists in finding a conserved secondary structure with minimum free energy in an ensemble of aligned sequences.
Nguyen Truong, Anwar Mohammad, Turcotte Marcel   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Strategies for measuring evolutionary conservation of RNA secondary structures

BMC Bioinformatics, 2008
Background Evolutionary conservation of RNA secondary structure is a typical feature of many functional non-coding RNAs. Since almost all of the available methods used for prediction and annotation of non-coding RNA genes rely on this evolutionary ...
Hofacker Ivo L, Bernhart Stephan H, Gruber Andreas R, Washietl Stefan   +3 more
doaj   +1 more source

A folding algorithm for extended RNA secondary structures

Bioinform., 2011
Motivation: RNA secondary structure contains many non-canonical base pairs of different pair families. Successful prediction of these structural features leads to improved secondary structures with applications in tertiary structure prediction and ...
C. H. Z. Siederdissen, S. Bernhart, Peter F. Stadler, I. Hofacker   +3 more
semanticscholar   +1 more source