Results 141 to 150 of about 1,632,786 (366)
Molecular basis for sortase-catalyzed pilus tip assembly
mBioDuring pilus assembly within the Gram-positive bacterial envelope, membrane-bound sortase enzymes sequentially crosslink specific pilus protein monomers through their cell wall sorting signals (CWSS), starting with a designated tip pilin, followed by the
Aadil H. Bhat +3 more
doaj +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
, 2012 nefficient intracellular protein trafficking is a critical issue in the pathogenesis of a variety of diseases and in recombinant protein production.
Tonn, Torsten +19 more
core +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Some effects of insect hormones on Na(^+), K(^+)-ATPase and fluid secretion by the malpighian tubules of locusta migratoria L [PDF]
, 1981 A study has been made on the effects of insect hormones on fluid secretion by the Malpighian tubules of Locusta, and on the Na(^+), K(^+)- ATPase activity in microsomal preparations of the tubules.
Donkin, Julie Ellison
core
, 2007 The present study was undertaken to determine the main metabolic secretory signals generated by the mitochondrial substrate MeS (methyl succinate) compared with glucose in mouse and rat islets and to understand the differences.
Schultz, Vera +10 more
core +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
, 2009 Kutatásunk célja polarizált epitheliális sejtek elektrolit és folyadékszekréciójának molekuláris szintű vizsgálata volt. Jól differenciált hasnyálmirigy duktusz Capan-1 és HPAF, valamint nyálmirigy acinus ParC10 és SMIE sejtvonalakat vizsgáltunk ...
Burghardt, Beáta
core