Results 11 to 20 of about 830,148 (206)

Type VI secretion system [PDF]

Current Biology, 2015
Bacteria employ a variety of tools to survive in a competitive environment. Salomon and Orth describe one such tool-the Type 6 Secretion Systems used by bacteria to deliver a variety of toxins into competing cells.
Salomon, Dor, Orth, Kim
openaire   +2 more sources

Translation/Secretion Coupling by Type III Secretion Systems [PDF]

Cell, 2000
Type III secretion systems mediate export of virulence proteins and flagellar assembly subunits in Gram-negative bacteria. Chaperones specific to each class of secreted protein are believed to prevent degradation of the secreted substrates. We show that an additional role of chaperones may be to regulate translation of secreted proteins.
Karlinsey, Joyce E, Lonner, Jay, Brown, Kit L, Hughes, Kelly T   +3 more
openaire   +2 more sources

Bacterial effector kinases and strategies to identify their target host substrates

Frontiers in Microbiology, 2023
Post-translational modifications (PTMs) are critical in regulating protein function by altering chemical characteristics of proteins. Phosphorylation is an integral PTM, catalyzed by kinases and reversibly removed by phosphatases, that modulates many ...
Brendyn M. St. Louis, Sydney M. Quagliato, Pei-Chung Lee   +2 more
doaj   +1 more source

Evolution of a cis-Acting SNP That Controls Type VI Secretion in Vibrio cholerae

mBio, 2022
Mutations in regulatory mechanisms that control gene expression contribute to phenotypic diversity and thus facilitate the adaptation of microbes and other organisms to new niches.
Siu Lung Ng, Sophia Kammann, Gabi Steinbach, Tobias Hoffmann, Peter J. Yunker, Brian K. Hammer   +5 more
doaj   +1 more source

Manipulation of host immune defenses by effector proteins delivered from multiple secretion systems of Salmonella and its application in vaccine research

Frontiers in Immunology, 2023
Salmonella is an important zoonotic bacterial species and hazardous for the health of human beings and livestock globally. Depending on the host, Salmonella can cause diseases ranging from gastroenteritis to life-threatening systemic infection.
Guodong Zhou, Guodong Zhou, Yuying Zhao, Yuying Zhao, Qifeng Ma, Qifeng Ma, Quan Li, Quan Li, Shifeng Wang, Huoying Shi, Huoying Shi, Huoying Shi   +11 more
doaj   +1 more source

Structure of HrcQ(B)-C, a conserved component of the bacterial type III secretion systems [PDF]

, 2003
Type III secretion systems enable plant and animal bacterial pathogens to deliver virulence proteins into the cytosol of eukaryotic host cells, causing a broad spectrum of diseases including bacteremia, septicemia, typhoid fever, and bubonic plague in ...
A. P. Tampakaki, Alfano, Anderson, Br  nger, Charkowski, Collmer, Fadouloglou, Francis, Galan, Garcia de la Torre, Gouet, Hueck, J. M. Hadden, Jin, Kubori, Landgraf, Lloyd, Luo, M. Kokkinidis, M. N. Bastaki, Mathews, McGuffin, Murshudov, N. J. Panopoulos, N. M. Glykos, Rossier, S. E. Phillips, Stebbins, Tamano, Tang, Terwilliger, Terwilliger, V. E. Fadouloglou, Zhao   +33 more
core   +2 more sources

The Tip of the VgrG Spike Is Essential to Functional Type VI Secretion System Assembly in Acinetobacter baumannii

mBio, 2020
The type VI secretion system (T6SS) is a critical weapon in bacterial warfare between Gram-negative bacteria. Although invaluable for niche establishment, this machine represents an energetic burden to its host bacterium.
Juvenal Lopez, Pek Man Ly, Mario F. Feldman   +2 more
doaj   +1 more source

Type VI secretion: a beginner's guide [PDF]

, 2008
Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria. Components that have been partially characterised include an IcmF homologue, the ATPase ClpV, a regulatory FHA domain protein and ...
Akeda, Baron, Bladergroen, Brzuszkiewicz, Christopher M Bailey, Dandekar, Das, Das, de Bruin, Dreyfus, Dudley, Dudley, Durocher, Economou, Finn, Folkesson, Gardy, Henderson, Johnson, Kulasekara, Lewis EH Bingle, Mark J Pallen, Mougous, Mougous, Nano, Pallen, Parsons, Pukatzki, Pukatzki, Purcell, Roest, Schell, Schlieker, Seshadri, Shalom, Sheahan, Srinivasa Rao, Tatusov, VanRheenen, Ventre, Wang, Weibezahn, Williams, Yahr, Yeo, Zheng, Zheng, Zusman   +47 more
core   +1 more source

Extra! Extracellular Effector Delivery into Host Cells via the Type 3 Secretion System

mBio, 2017
The type three secretion system (T3SS) is critical for the virulence of diverse bacterial pathogens. Pathogens use the T3SS to deliver effector proteins into host cells and manipulate host signaling pathways.
Melissa M. Kendall
doaj   +1 more source

Subcellular Location of Piscirickettsia salmonis Heat Shock Protein 60 (Hsp60) Chaperone by Using Immunogold Labeling and Proteomic Analysis

Microorganisms, 2020
Piscirickettsia salmonis is the causative bacterial agent of piscirickettsiosis, a systemic fish disease that significantly impacts the Chilean salmon industry.
Cristian Oliver, Patricio Sánchez, Karla Valenzuela, Mauricio Hernández, Juan Pablo Pontigo, Maria C. Rauch, Rafael A. Garduño, Ruben Avendaño-Herrera, Alejandro J. Yáñez   +8 more
doaj   +1 more source