Results 231 to 240 of about 242,930 (301)

The uterine secretome initiates growth of gynecologic tissues in ectopic locations: re-evaluating the evidence. [PDF]

Pathol Oncol Res
Sunde J, Pennington KA.
europepmc   +1 more source

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source

Secretome and Transcriptome Analyses Reveal New Potential Virulence Factors during <i>Cryptosporidium parvum</i> Invasion. [PDF]

J Proteome Res
Li N, Cui Z, Wang L, Sun S, Zhao W, Wang Y, Meng Q, Li X, Zhang S, Wu Y, Zhang L.   +10 more
europepmc   +1 more source

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

Animal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong, Wei Qian, Deji Song, Kang Li, Li Zhang, Li Shi   +5 more
wiley   +1 more source

Integrated bioinformatics analysis reveals Netrin-1 as a key molecular link between Parkinson's disease and heart failure. [PDF]

Front Aging Neurosci
Ni Z, Wang G, Li Y, Chen H, Hou H, Hu Q.
europepmc   +1 more source

Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects

Animal Models and Experimental Medicine, EarlyView.
Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu, Jiaqi Chen, Zhonghui Li, Jiamin Zhou, Hui Zhang, Yujia Yu, Feng Cheng, Jie Bao, Chunhan Feng, Xiangqu Yu, Zhao Xia, Rao Ding, Xiang Li   +12 more
wiley   +1 more source

From mucus secretion to immune surveillance: the evolving roles of goblet cells in intestinal homeostasis and inflammation. [PDF]

Front Immunol
Du N, Zhang K, Guo J, Yan W, Xu L.
europepmc   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening. [PDF]

Eur J Immunol
Mamorita S, Furukawa A, Nagata Y, Suzuki R.   +3 more
europepmc   +1 more source