Development of horse neutralizing immunoglobulin and immunoglobulin fragments against Junín virus. [PDF]
Antiviral Res, 2020 Argentine haemorrhagic fever (AHF) is a rodent-borne disease with a lethality as high as ~30%, which is caused by the New World arenavirus, Junín virus (JUNV). It was once a major epidemic in South America and puts millions of people in Argentina at risk. Here, we aimed to develop horse antibodies or antibody fragments against JUNV.
Pan X, Wu Y, Wang W, Zhang L, Xiao G.
europepmc +3 more sources
Crescentic IgM-κ Monoclonal Immunoglobulin Deposition Disease with Thrombotic Microangiopathy in Waldenström’s Macroglobulinemia: A Rare and Aggressive Monoclonal Gammopathy of Renal Significance Presentation – A Case Report and Literature Review [PDF]
Glomerular DiseasesIntroduction: Monoclonal immunoglobulin deposition disease (MIDD) is a rare monoclonal gammopathy of renal significance (MGRS) characterized by linear, non-organized deposition of immunoglobulin fragments along glomerular, tubular, and ...
Chalermchon Suttaluang +3 more
doaj +2 more sources
Equine-Origin Immunoglobulin Fragments Protect Nonhuman Primates from Ebola Virus Disease [PDF]
Journal of Virology, 2019 Gary Wong, Hualei Wang, Songtao Yang
exaly +2 more sources
Frontiers in Immunology, 2023 The emergence of SARS-CoV-2 variants stresses the continued need for broad-spectrum therapeutic antibodies. Several therapeutic monoclonal antibodies or cocktails have been introduced for clinical use.
Entao Li +18 more
doaj +1 more source
Producing amyloid fibrils in vitro: A tool for studying AL amyloidosis
Biochemistry and Biophysics Reports, 2023 Amyloid light-chain (AL) amyloidosis is the second most common form of systemic amyloidosis which is characterized by a high level of mortality and no effective treatment to remove fibril deposition.
Daria V. Sizova +7 more
doaj +1 more source
A rare case of systemic AL-amyloidosis under the mask of myocardial infarction in the absence of myocardial hypertrophy: case report [PDF]
КардиоСоматика, 2022 Systemic amyloidosis is a group of diseases associated with extracellular deposition of fibrillar proteins, resulting in the loss of normal organ structure and function. AL-amyloidosis occurs when amyloid is deposited, consisting of full-length lambda or
Svetlana A. Boldueva +4 more
doaj +1 more source
Zoonoses, 2023 Smallpox, a severe infectious disease caused by the smallpox virus, causes a death rate as high as 30% within 15-20 days after infection. Therefore, development of anti-Smallpox product as a strategic reserve is urgently needed.
Bochang Shi +16 more
doaj +1 more source
The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement
Nature Communications, 2022 Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus +13 more
doaj +1 more source
EJNMMI Research, 2023 Background Following resection and standard adjuvant radio- and chemotherapy, approved maintenance therapies for glioblastoma are lacking. Intracavitary radioimmunotherapy (iRIT) with 177Lu-labeled 6A10-Fab fragments targeting tumor-associated carbonic ...
Wolfgang Roll +10 more
doaj +1 more source
Anti-SARS-CoV-2 equine F (Ab′)2 immunoglobulin as a possible therapy for COVID-19
Scientific Reports, 2022 The new outbreak of coronavirus disease 2019 (COVID-19) has infected and caused the death of millions of people worldwide. Intensive efforts are underway around the world to establish effective treatments.
Viviane Fongaro Botosso +35 more
doaj +1 more source