Results 41 to 50 of about 101,155 (265)

Refinement of an ovine-based immunoglobulin therapy against SARS-CoV-2, with comparison of whole IgG versus F(ab′)2 fragments

Scientific Reports, 2023
The development of new therapies against SARS-CoV-2 is required to extend the toolkit of intervention strategies to combat the global pandemic. In this study, hyperimmune plasma from sheep immunised with whole spike SARS-CoV-2 recombinant protein has ...
Stephen Findlay-Wilson, Linda Easterbrook, Sandra Smith, Neville Pope, Matthew Aldridge, Gareth Humphries, Holger Schuhmann, Didier Ngabo, Emma Rayner, Ashley Otter, Thomas Coleman, Bethany Hicks, Rachel Halkerston, Kostis Apostolakis, Stephen Taylor, Susan Fotheringham, Amanda Horton, Irene CanoCejas, Matthew Wand, Julia A. Tree, Mark Sutton, Victoria Graham, Roger Hewson, Stuart Dowall   +23 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Generation and functional characterization of a single-chain variable fragment (scFv) of the anti-FGF2 3F12E7 monoclonal antibody

Scientific Reports, 2021
Single-chain variable fragments (scFvs) are small-sized artificial constructs composed of the immunoglobulin heavy and light chain variable regions connected by a peptide linker.
Rodrigo Barbosa de Aguiar, Tábata de Almeida da Silva, Bruno Andrade Costa, Marcelo Ferreira Marcondes Machado, Renata Yoshiko Yamada, Camila Braggion, Kátia Regina Perez, Marcelo Alves Silva Mori, Vitor Oliveira, Jane Zveiter de Moraes   +9 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Comparison of total immunoglobulin G antibody responses to different protein fragments of Plasmodium vivax Reticulocyte binding protein 2b

Malaria Journal, 2022
Background Plasmodium vivax is emerging as the dominant and prevalent species causing malaria in near-elimination settings outside of Africa. Hypnozoites, the dormant liver stage parasite of P.
Caitlin Bourke, Eizo Takashima, Li-Jin Chan, Melanie H. Dietrich, Ramin Mazhari, Michael White, Jetsumon Sattabongkot, Wai-Hong Tham, Takafumi Tsuboi, Ivo Mueller, Rhea Longley   +10 more
doaj   +1 more source

Immuno-capture of biomolecules on functionalized magnetic beads: From characterization to fluorescent detection of a biomarker for Alzheimer's disease toward high performance biosensing

Talanta Open, 2023
It is reported herein a new approach to study the orientation and density of mouse antibody grafting on magnetic beads, serving for immunoassays and biosensors with fluorescent detection of biomolecules.
Ngoc Van Thanh Nguyen, Claire Smadja, Myriam Taverna, Trong Khoa Mai, Frédéric Halgand, Thanh Duc Mai   +5 more
doaj   +1 more source

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems

Advanced Functional Materials, EarlyView.
Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco, Valerio Francesco Annese, Valerio Galli, Ilaria Penna, Debora Russo, Marina Veronesi, Rita Scarpelli, Stefania Sabella, Mario Caironi   +8 more
wiley   +1 more source

OPTIMIZATION OF PRESENTATION AND CONSUMER CONTAINER OF ANTI-RABIES IMMUNOGLOBULIN OBTAINED FROM HORSE SERUM

Acta Biomedica Scientifica, 2012
We presented the data concerning optimization of presentation and consumer container of anti-rabies immunoglobulin obtained, from horse serum.. During the experiments, ampoules and. flasks were used for primary packaging.
N. N. Kochkalova, E. G. Abramova, A. K. Nikiforov, M. N. Kireyev, O. A. Lobovikova, L. V. Savitskaya, S. A. Badarin, S. V. Generalov, N. I. Kostyleva, N. A. Sharapova, Yu. V. Ivanov   +10 more
doaj  

Reconfigurable Au Nanoparticle Monolayers on Regenerated Cellulose Hydrogels: Highly Sensitive SERS Detection of Polystyrene Micro/Nanoplastics With Interpretable Deep Learning

Advanced Functional Materials, EarlyView.
A regenerated cellulose (RC) hydrogel‐based SERS substrate integrating a Marangoni‐transferred gold nanoparticle self‐assembled monolayer (Au‐SAM) is fabricated. Reswelling‐induced hotspot formation enhances polystyrene micro/nanoplastics (PS MNPs) detection in complex matrices, providing reproducible, high‐throughput SERS signals across diverse ...
Youngho Jeon, Yu‐Jin Jeon, Suji Lee, Jeseong Kim, Dae‐Hyun Jung, Jungmok You   +5 more
wiley   +1 more source

DNA Ligase I Is Not Essential for Mammalian Cell Viability

Cell Reports, 2014
Summary: Of the three DNA ligases present in all vertebrates, DNA ligase I (Lig1) has been considered essential for ligating Okazaki fragments during DNA replication and thereby essential for cell viability.
Li Han, Shahnaz Masani, Chih-lin Hsieh, Kefei Yu   +3 more
doaj   +1 more source