Results 61 to 70 of about 242,930 (301)

STATE OF URINARY TRACTS’IMMUNITYINPATIENTS WITH ACUTE PYELONEPHRITIS AND CYSTITIS

open access: yesУкраїнський Журнал Нефрології та Діалізу, 2014
Materials and methods. 64 patients with acute pyelonephritis (AP) and 15 healthy women were examined. in urine were determined indices which characterized a state of urinary tracts’ immunity.
A. Rudenko   +3 more
doaj   +1 more source

A novel two-component system involved in the transition to secondary metabolism in Streptomyces coelicolor. [PDF]

open access: yesPLoS ONE, 2012
BACKGROUND: Bacterial two-component signal transduction regulatory systems are the major set of signalling proteins frequently mediating responses to changes in the environment.
Daniel Rozas   +2 more
doaj   +1 more source

Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis

open access: yesCell Reports, 2021
Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA
Nicolas Rochereau   +9 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

The pathways of secretory cargo export at the endoplasmic reticulum

open access: yesNature Communications
Palade’s original model proposed that secretory cargo is transported between stable compartments via vesicles. However, recent findings challenge this view, suggesting that secretory pathway compartments are dynamic, with cargo itself dictating whether ...
Vivek Malhotra
doaj   +1 more source

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]

open access: yes, 2013
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E.   +4 more
core   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.

open access: yesPLoS Biology, 2013
Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and their
Birgitte Holst   +17 more
doaj   +1 more source

MR imaging findings of a rare pediatric parotid tumor: Mammary analogue secretory carcinoma

open access: yesRadiology Case Reports, 2020
We present magnetic resonance imaging findings of an 11-year-old girl with a mammary analogue secretory carcinoma (MASC) of the parotid gland. MASC is a recently described tumor of the salivary glands that is genetically and histologically similar to ...
Daniel Helmy, MD   +5 more
doaj   +1 more source

Sdmg1 is a component of secretory granules in mouse secretory exocrine tissues [PDF]

open access: yesDevelopmental Dynamics, 2008
AbstractSdmg1 is a conserved eukaryotic transmembrane protein that is mainly expressed in the gonads where it may have a role in mediating signaling between somatic cells and germ cells. In this study we demonstrate that secretory exocrine cells in the pancreas, salivary gland, and mammary gland also express Sdmg1.
Diana, Best, Ian R, Adams
openaire   +2 more sources

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