Results 261 to 270 of about 321,020 (307)
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Quality control in the secretory pathway
Current Opinion in Cell Biology, 1995Whereas newly synthesized proteins that have acquired a properly folded and assembled structure are transported from the endoplasmic reticulum to their final destinations, incompletely folded and assembled proteins are, as a rule, retained and eventually degraded.
C, Hammond, A, Helenius
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Molecular dissection of the secretory pathway
Nature, 1992A combination of biochemistry in animal cell-free systems and genetics in yeast is revealing the molecular machinery of the secretory pathway of eukaryotes. Transporting vesicles have a simple coat structure and employ a general mechanism for fusion that is conserved in evolution.
J E, Rothman, L, Orci
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A NOVEL PATHWAY FOR SECRETORY PROTEINS?
Trends in Biochemical Sciences, 1990In eukaryotes, most proteins which are transported to the extracellular space, into mitochondria or into chloroplasts are synthesized as precursor polypeptides containing cleavable N-terminal signal or targeting sequences. We have searched the literature for proteins that are exported from the cytosol without being proteolytically processed.
MUESCH A. +5 more
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Neurotrophin secretory pathways and synaptic plasticity
Neurobiology of Aging, 2003Neurotrophins and synaptic activity work in conjunction during the process of synaptic plasticity. Both are required to stabilize new synaptic structures and the loss of either can lead to cognitive impairments, as new information cannot be stored efficiently or later recalled.
Kuei-Cheng, Lim +2 more
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The perplexing PEXEL protein secretory pathway
Nature Microbiology, 2018Plasmodium parasites possess a unique PEXEL sorting pathway to deliver secretory proteins into the host cells in which they reside. A new study shows the existence of independent sorting/entry complexes to detect and deliver PEXEL proteins into the parasite endoplasmic reticulum.
Pool, Martin, Russo, Ilaria
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Molecular Sorting in the Secretory Pathway
Science, 1989Proteins can be secreted from animal cells by either a constitutive or a regulated pathway; those destined for regulated secretion are actively sorted into dense-core secretory granules. Although sorting is generally assumed to be accomplished by specific carriers, the nature of these carriers remains elusive.
K N, Chung +3 more
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Tyrosine Sulfation and the Secretory Pathway
Annual Review of Physiology, 1988Tyrosine sulfation is a widespread posttranslational modification. Most tyrosine-sulfated proteins identified so far are secretory, including several neuropeptides. Tyrosine sulfation occurs in the trans Golgi and is one of the last processing steps before proteins exit from the Golgi complex.
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Green light for the secretory pathway
Protoplasma, 1999Since the advent of green-fluorescent protein (GFP) technology there has been an explosion of interest in applying this molecule to cell biology. This review summarizes new insights in secretory membrane traffic obtained by the use of GFP fusion proteins.
H H, Gerdes, R, Rudolf
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1994
Abstract This, the latest in the Sambrook and Tooze Guidebook Series enables non-specialists to rapidly gain access to unfamiliar work surrounding the secretory pathways. Detailing both the established and the experimental, this book outlines how recent work has established a role for the secretory pathway in the regulation of gene ...
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Abstract This, the latest in the Sambrook and Tooze Guidebook Series enables non-specialists to rapidly gain access to unfamiliar work surrounding the secretory pathways. Detailing both the established and the experimental, this book outlines how recent work has established a role for the secretory pathway in the regulation of gene ...
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Entering the secretory pathway
1994Abstract In prokaryotic and eukaryotic cells, specialized processes such as secretion and signal transduction, as well as the enzymatic reactions of intermediary metabolism, are organized into membranes and membrane-enclosed compartments.
Jonathan Rothblatt +2 more
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