Results 271 to 280 of about 326,424 (312)

Molecular Sorting in the Secretory Pathway

Science, 1989
Proteins can be secreted from animal cells by either a constitutive or a regulated pathway; those destined for regulated secretion are actively sorted into dense-core secretory granules. Although sorting is generally assumed to be accomplished by specific carriers, the nature of these carriers remains elusive.
K N, Chung, P, Walter, G W, Aponte, H P, Moore   +3 more
openaire   +2 more sources

Tyrosine Sulfation and the Secretory Pathway

Annual Review of Physiology, 1988
Tyrosine sulfation is a widespread posttranslational modification. Most tyrosine-sulfated proteins identified so far are secretory, including several neuropeptides. Tyrosine sulfation occurs in the trans Golgi and is one of the last processing steps before proteins exit from the Golgi complex.
openaire   +2 more sources

Green light for the secretory pathway

Protoplasma, 1999
Since the advent of green-fluorescent protein (GFP) technology there has been an explosion of interest in applying this molecule to cell biology. This review summarizes new insights in secretory membrane traffic obtained by the use of GFP fusion proteins.
H H, Gerdes, R, Rudolf
openaire   +2 more sources

Secretory Pathway

1994
Abstract This, the latest in the Sambrook and Tooze Guidebook Series enables non-specialists to rapidly gain access to unfamiliar work surrounding the secretory pathways. Detailing both the established and the experimental, this book outlines how recent work has established a role for the secretory pathway in the regulation of gene ...
openaire   +1 more source

Entering the secretory pathway

1994
Abstract In prokaryotic and eukaryotic cells, specialized processes such as secretion and signal transduction, as well as the enzymatic reactions of intermediary metabolism, are organized into membranes and membrane-enclosed compartments.
Jonathan Rothblatt, Peter Novick, Tom H Stevens   +2 more
openaire   +1 more source

Protein processing within the secretory pathway

Current Opinion in Biotechnology, 1992
Endoproteolytic cleavage of hormone and neuropeptide precursors, as well as many complex proteins, such as coagulation factors and viral glycoproteins, is a key process in the generation of bioactive polypeptides. These cleavages typically occur at the dibasic amino acid residues Lys-Arg or Arg-Arg.
A, Rehemtulla, R J, Kaufman
openaire   +2 more sources

Compartments of the Early Secretory Pathway

1994
The secretory pathway consists of a set of compartments responsible for the assembly and modification of proteins destined for secretion, for transport to the plasma membrane, and to the other organelles of the cell. The classical description of the secretory pathway comprises the endoplasmic reticulum (ER) as the site of protein synthesis and first ...
R J, Hendriks, S D, Fuller
openaire   +2 more sources

Lumenal protein multimerization in the distal secretory pathway/secretory granules

Current Opinion in Cell Biology, 2002
Differences in protein solubility appear to play an important role in lumenal protein trafficking through Golgi/post-Golgi compartments. Recent advances indicate that multimeric protein assembly is one of the factors regulating the efficiency of protein storage within secretory granules, by mechanisms that, with slight modification, might be considered
Peter, Arvan, Bao-yan, Zhang, Lijun, Feng, Ming, Liu, Regina, Kuliawat   +4 more
openaire   +2 more sources

Secretory Pathway Function in Saccharomyces cerevisiae

1992
A genetic analysis of secretory pathway function in yeast was initiated some 12 years ago in the laboratory of Randy Schekman. These mutants held great promise in terms of providing an experimental system with which molecular participants of secretory pathway function could be investigated. This early promise has not failed.
A E, Cleves, V A, Bankaitis
openaire   +2 more sources

Secretory Pathway

2006
  +4 more sources