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Protein processing within the secretory pathway
Current Opinion in Biotechnology, 1992Endoproteolytic cleavage of hormone and neuropeptide precursors, as well as many complex proteins, such as coagulation factors and viral glycoproteins, is a key process in the generation of bioactive polypeptides. These cleavages typically occur at the dibasic amino acid residues Lys-Arg or Arg-Arg.
A, Rehemtulla, R J, Kaufman
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Compartments of the Early Secretory Pathway
1994The secretory pathway consists of a set of compartments responsible for the assembly and modification of proteins destined for secretion, for transport to the plasma membrane, and to the other organelles of the cell. The classical description of the secretory pathway comprises the endoplasmic reticulum (ER) as the site of protein synthesis and first ...
R J, Hendriks, S D, Fuller
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Lumenal protein multimerization in the distal secretory pathway/secretory granules
Current Opinion in Cell Biology, 2002Differences in protein solubility appear to play an important role in lumenal protein trafficking through Golgi/post-Golgi compartments. Recent advances indicate that multimeric protein assembly is one of the factors regulating the efficiency of protein storage within secretory granules, by mechanisms that, with slight modification, might be considered
Peter, Arvan +4 more
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Secretory Pathway Function in Saccharomyces cerevisiae
1992A genetic analysis of secretory pathway function in yeast was initiated some 12 years ago in the laboratory of Randy Schekman. These mutants held great promise in terms of providing an experimental system with which molecular participants of secretory pathway function could be investigated. This early promise has not failed.
A E, Cleves, V A, Bankaitis
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Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
Nature Reviews Drug Discovery, 2020Anwesha Dey +2 more
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