Results 81 to 90 of about 1,456,577 (296)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Intervention Methods in Secure Care: What Is Going on for Society’s Most Vulnerable Children?

Social Sciences
Secure care is used for the most vulnerable and high-risk children in society; however, there is insufficient research examining the way intervention methods are used in this context.
Gavin Heron, Ross Gibson
doaj   +1 more source

State-Level and County-Level Estimates of Health Care Costs Associated with Food Insecurity. [PDF]

, 2019
IntroductionFood insecurity, or uncertain access to food because of limited financial resources, is associated with higher health care expenditures. However, both food insecurity prevalence and health care spending vary widely in the United States.
Basu, Sanjay, Berkowitz, Seth A, Gundersen, Craig, Seligman, Hilary K   +3 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Resilience and survival : black teenage mothers 'looked after' by the State tell their stories about their experience of care [PDF]

, 2013
This is the peer reviewed version of the following article: Nadia Mantonavi, and Hilary Thomas, 'Resilience and Survival: Black Teenage Mothers ‘Looked After’ by the State Tell their Stories About their Experience of Care', Children & Society, Vol. 29 (4)
Akister, Audit Commission, Bandura, Barn, Biehal, Bonell, Bullock, Chase, Cheung, Chevalier, Corlyon, Cusick, Davis, Dearden, Denzin, Department for Education, Department for Education and Skills, Department for Education and Skills, Department for Education and Skills, Department of Health, Department of Health, Dobson, Dominelli, Driscoll, Garmezy, Gilligan, Graham, Hudson, Joseph Rowntree Foundation, Julca, Knight, Kobasa, Kohli, Masten, Maynard, McLeod, McMurray, Oakley, Roy, Sandler, Sellick, Shaikh, Social Exclusion Unit, Social Exclusion Unit (SEU), Strauss, Thompson, Tronto, Youth Justice Board   +47 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Networked Behaviors Associated With a Large-Scale Secure Messaging Network: Cross-Sectional Secondary Data Analysis

JMIR Medical Informatics
BackgroundCommunication among health care professionals is essential for effective clinical care. Asynchronous text-based clinician communication—secure messaging—is rapidly becoming the preferred mode of communication.
Laura Rosa Baratta, Linlin Xia, Daphne Lew, Elise Eiden, Y Jasmine Wu, Noshir Contractor, Bruce L Lambert, Sunny S Lou, Thomas Kannampallil   +8 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Securing safer care staff: a model for the assessment, selection and training of staff to work in residential care

Scottish Journal of Residential Child Care, 2006
The recruitment of staff into residential child care presents an ongoing challenge for organisations. Methods of recruitment in the past have been criticised in a range of government reports. Skinner (1992) and others have highlighted the need for better
John Watson, Janice Gould, Gerry Sullivan, Jayne Cockerill   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source