Results 91 to 100 of about 4,663,317 (279)

An exploration of service users' experiences of a low secure forensic mental health service [PDF]

open access: yes, 2008
This is an exploratory study of the experiences of service users in forensic mental health settings, including how service users make sense of these experiences and their link to identity.
Wilkinson, Catherine Elizabeth
core   +3 more sources

Physicians’ Experiences Using Secure Messaging for Diabetes Management: A Qualitative Study

open access: yesJMIR Diabetes
BackgroundThe COVID-19 pandemic led to increased demand for remote management of type 2 diabetes using secure messaging, or patient-provider text-based communication.
Ben Kragen   +5 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

The Personal Health Record Paradox: Health Care Professionals’ Perspectives and the Information Ecology of Personal Health Record Systems in Organizational and Clinical Settings

open access: yesJournal of Medical Internet Research, 2013
BackgroundDespite significant consumer interest and anticipated benefits, overall adoption of personal health records (PHRs) remains relatively low. Understanding the consumer perspective is necessary, but insufficient by itself.
Nazi, Kim M
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

'Don't take it home with you': Views of secure care staff on debrief after restraint

open access: yesScottish Journal of Residential Child Care
There is a dearth of research into debrief after restraint in secure and residential childcare. This research sought the views of care workers on debrief practice across three secure centres in Scotland, using a mixed methods qualitative approach. It was
Abbi Jackson
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Adjusting the volume: the paradoxical experience of secure care for autistic young people

open access: yesScottish Journal of Residential Child Care
This paper explores the impact of secure care on the identity narratives of autistic young people. The research made use of a flexible diary method and semistructured interviews, analysed using interpretative phenomenological analysis (IPA).
Charlotte Wilson
doaj   +1 more source

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