Results 71 to 80 of about 4,663,317 (279)

Secure Role-based Messaging [PDF]

, 2005
This paper describes a secure role based messaging system design based on the use of X.509 Attribute Certificates for holding user roles. Access to the mes-sages is authorised by the PERMIS Privilege Management Infrastructure, a pol-icy driven role based
Lunt, Graeme, Zhao, Gansen, Chadwick, David, Graeme Lunt, David Chadwick, Gansen Zhao   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Networked Behaviors Associated With a Large-Scale Secure Messaging Network: Cross-Sectional Secondary Data Analysis

JMIR Medical Informatics
BackgroundCommunication among health care professionals is essential for effective clinical care. Asynchronous text-based clinician communication—secure messaging—is rapidly becoming the preferred mode of communication.
Laura Rosa Baratta, Linlin Xia, Daphne Lew, Elise Eiden, Y Jasmine Wu, Noshir Contractor, Bruce L Lambert, Sunny S Lou, Thomas Kannampallil   +8 more
doaj   +1 more source

Reconciling security and care in digital medicine

npj Digital Medicine
Abstract Common approaches to cybersecurity frame end users as the weakest link in a system. In this Perspective, we argue that appraising end users as contributors to security can help reconcile both security and care practices. Through two case studies, including Swedish hospitals and a UK smart-home system, we demonstrate the gaps between ...
Chiara Carboni, Celia Brightwell, Orit Halpern, Oscar Freyer, Stephen Gilbert   +4 more
openaire   +5 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Securing safer care staff: a model for the assessment, selection and training of staff to work in residential care

Scottish Journal of Residential Child Care, 2006
The recruitment of staff into residential child care presents an ongoing challenge for organisations. Methods of recruitment in the past have been criticised in a range of government reports. Skinner (1992) and others have highlighted the need for better
John Watson, Janice Gould, Gerry Sullivan, Jayne Cockerill   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Adjusting the volume: reflections on engagement with autistic young people living in secure care

Scottish Journal of Residential Child Care
In undertaking a doctoral research project looking at the impact of Scottish secure care experience on the identity constructions of autistic young people, I experienced a number of unexpected challenges with engagement.
Charlotte Wilson
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source