Results 71 to 80 of about 1,456,577 (296)

A comparative review of palliative care development in six countries represented by the Middle East Cancer Consortium (MECC) [PDF]

, 2009
Palliative care development and services were reviewed in the region represented by the six members of the Middle East Cancer Consortium: Cyprus, Egypt, Israel, Jordan, the Palestinian Authority, and Turkey.
Amanda Bingley, Bercovitch, David Clark, Freedman, International Narcotics Control Board, International Narcotics Control Board, Oguz, Sapir, Stjernswärd, Stjernswärd, Ward, Wright   +11 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Women's secure hospital care pathways in practice: a qualitative analysis of clinicians views in England and Wales [PDF]

, 2014
BACKGROUND: In England and Wales women form a small but significant group within the wider, largely male, secure hospital population. Secure hospitals are designed to assess and treat individuals with both mental health problems and significant criminal ...
A Bartlett, A Bartlett, A Bartlett, A Maden, Annie Bartlett, C Marshall, College Centre for Quality Improvement, CCQI, Department of Health, Department of Health, Department of Health & Home Office, Department of Health, DH, Department of Health, DH, FR David, G Adshead, G Adshead, G Durcan, G Freeman, G Long, G Mezey, G Panagiotou, HG Kennedy, J Coid, J Coid, J Coid, J Corston, J Sarkar, L Kreftling, M Barber, M Harty, N Davis, N Piercy, Nadia Somers, R Fritchie, Royal College of Psychiatrists, S Covington, S Covington, S Middleton, S Wilson, T Benson, The Centre for Economic Performance’s Mental Health Policy Group, V Braun   +40 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Secure Care (PDF 301KB)

, 2002
An Inspection of Secure Accommodation at Shamrock House and Linden ...
Department of Health, Social Services and Public Safety   +1 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Secure Care in Australia—An Overview of Secure Care in Australian States and Territories and Commentary on the Legal Safety of Children Admitted to Secure Care in Australia

Social Sciences
There is very limited information available on secure care in Australia. There is no national oversight, standards, or data collection mechanisms. This article aims to outline which Australian states and territories deliver secure care, provide an ...
Kate Crowe
doaj   +1 more source

The Hospital at Home Model: Bringing Hospital-Level Care to the Patient [PDF]

, 2016
Presbyterian's Hospital at Home program, launched in 2008, is based on a model developed in the mid-1990s by Bruce Leff, M.D., a geriatrician and health services researcher at Johns Hopkins University, who noticed that many of his patients suffered poor ...
Douglas McCarthy, Martha Hostetter, Sarah Klein   +2 more
core  

The role of primary care in adult weight management: qualitative interviews with key stakeholders in weight management services [PDF]

, 2017
Background: Primary care has a key role to play in the prevention and management of obesity, but there remain barriers to engagement in weight management by primary care practitioners.
Blane, David N., Macdonald, Sara, Morrison, David, O'Donnell, Catherine A.   +3 more
core   +2 more sources