Results 121 to 130 of about 206,888 (308)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Avaliação das alterações da saturação periférica de oxigênio, da tensão arterial e do pulso em pacientes submetidos à sedação consciente para endoscopia digestiva alta [PDF]
, 2009 Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Kauling, Ana Laura Colle
core
Frontiers in PediatricsObjectivesThe procedural sedation for young children, especially in infants under 3 months old, and those with congenital heart disease (CHD) is relatively challenging and risky.
Jingjing Lv, Lihong Jin
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Intensive care unit sedation: nurses monitoring techniques
reservedDescrizione delle varie tecniche di monitoraggio in relazione alle problematiche conseguenti alla sedazione in terapia intensiva, con analisi delle cause principali di scompenso nel paziente.Description of the various monitoring techniques in ...
SATTIN, ALESSIA
core
Canadian Medical Association Journal, 2014 Romayne, Gallagher, Caroline, Baldwin
openaire +5 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Sedation with dexmedetomidine in the intensive care setting
, 2011 Anthony T Gerlach, Claire V Murphy The Ohio State University Medical Center, Ohio State University, Columbus, OH, USA Abstract: Dexmedetomidine is an α-2 agonist that produces sedation and analgesia without compromising the respiratory drive ...
Murphy CV, Gerlach AT
core
Anesthesia or sedation for gastroenterologic endoscopies
, 2009 PURPOSE OF REVIEW: Because propofol is the sedative preferred by gastroenterologists, we focus this review on gastroenterologist-directed propofol sedation, provide simulations of the respiratory depressant effect of different dosing protocols and give a
Stüber, Frank +3 more
core +1 more source