Results 101 to 110 of about 242,778 (310)

Pediatric dental sedation: challenges and opportunities

, 2015
Travis M Nelson, Zheng Xu Department of Pediatric Dentistry, University of Washington, Seattle, WA, USA Abstract: High levels of dental caries, challenging child behavior, and parent expectations support a need for sedation in pediatric dentistry.
Nelson TM, Xu Z
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Use of sedation-awakening electroencephalography in dogs with epilepsy. [PDF]

BACKGROUND Electroencephalography (EEG) recording protocols have been standardized for humans. Although the utilization of techniques in veterinary medicine is increasing, a standard protocol has not yet been established.
Płonek, Marta, Banasik, Aleksandra, Czerwik, Adriana, Stein, Veronika, Wrzosek, Marcin, Olszewska, Agnieszka   +5 more
core   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

National Consensus on the Use of Sedation Drugs in the Gastrointestinal Endoscopic Procedures

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2017
Gastrointestinal endoscopy is rapidly developing and several gastrointestinal endoscopy equipment are available for both diagnostic and therapeutic purposes.
Daldiyono, Abdul Aziz Rani, Marcellus Simadibrata, Ari Fahrial Syam, Achmad Fauzi, Dadang Makmun, Murdani Abdullah,, Indra Marki, Kaka Renaldi   +8 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Nomogram for predicting the success rate of sedation with intranasal dexmedetomidine in paediatric nonpainful diagnostic procedures: a retrospective study

Scientific Reports
Intranasal dexmedetomidine (IN DEX) is being increasingly used for sedation in children undergoing nonpainful diagnostic procedures. Successful procedural sedation facilitates rapid and accurate clinical diagnosis and treatment, thereby improving ...
Huatian Lin, Lihua Gao, Ningning Cui, Guangwu Liao, Xueqing Wang, Taohua Peng, Yuetao Xie   +6 more
doaj   +1 more source

Sedation Monitoring and Management during Percutaneous Endoscopic Lumbar Discectomy

Case Reports in Anesthesiology, 2016
Percutaneous endoscopic laser discectomy (PELD) is a painful intervention that requires deep sedation and analgesia. However, sedation should be light at some point because cooperation by the patient during the procedure is required for successful ...
Menekse Oksar, Tulin Gumus, Orhan Kanbak
doaj   +1 more source

Sedation with dexmedetomidine in the intensive care setting

, 2011
Anthony T Gerlach, Claire V Murphy The Ohio State University Medical Center, Ohio State University, Columbus, OH, USA Abstract: Dexmedetomidine is an α-2 agonist that produces sedation and analgesia without compromising the respiratory drive ...
Murphy CV, Gerlach AT
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source