Results 91 to 100 of about 297,575 (306)
Factors associated with the efficacy of polyp detection during routine flexible sigmoidoscopy [PDF]
, 2017 Objective: Flexible sigmoidoscopy reduces the incidence of colonic cancer through the detection and removal of premalignant adenomas. However, the efficacy of the procedure is variable.
Anderson, John H. +4 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Analysis of procedural sedation nursing practice in the pediatric wards of a tertiary hospital in South Korea: a retrospective descriptive study [PDF]
Child Health Nursing ResearchPurpose To analyze the general, clinical, and sedation-related characteristics of pediatric inpatients who received procedural sedation from pediatric sedation nurses, and to identify the incidence of sedation-related adverse events and sedation failure.
Ji-Eun Jung, Kyung-Sook Bang
doaj +1 more source
The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees? [PDF]
, 2017 Could new oral vaccine technologies protect endangered wildlife against a rising tide of infectious disease? We used captive chimpanzees to test oral delivery of a rabies virus (RABV) vectored vaccine against Ebola virus (EBOV), a major threat to wild ...
Goetzmann, Jason E. +5 more
core +2 more sources
Colonoscopy without Sedation [PDF]
Scandinavian Journal of Gastroenterology, 2000 (2000). Colonoscopy without Sedation. Scandinavian Journal of Gastroenterology: Vol. 35, No. 3, pp. 225-226.
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Scientific ReportsIntranasal dexmedetomidine (IN DEX) is being increasingly used for sedation in children undergoing nonpainful diagnostic procedures. Successful procedural sedation facilitates rapid and accurate clinical diagnosis and treatment, thereby improving ...
Huatian Lin +6 more
doaj +1 more source
A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors [PDF]
, 2019 Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol.
Bocarsly, Miriam E. +8 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Patient anxiety and modern elective surgery: a literature review [PDF]
, 2003 Medical advances have led to a considerable rise in the level of elective surgery undertaken as day-case surgery and with minimal hospital stay. However, amid such advances, preoperative psychological care has remained relatively static.
Mitchell, MJ
core +1 more source