Results 91 to 100 of about 206,888 (308)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
National Consensus on the Use of Sedation Drugs in the Gastrointestinal Endoscopic Procedures
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2017 Gastrointestinal endoscopy is rapidly developing and several gastrointestinal endoscopy equipment are available for both diagnostic and therapeutic purposes.
Daldiyono +8 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Comparison of Hemodynamic and Sedation Effects of Midazolam and Propofol
, 2015 Aim: In this study, we compared the sedation quality and cardiovascular and respiratory system effects of midazolam versus propofol in patients undergoing spinal anesthesia. Methods: 40 ASA I-III patients aged 20-70 years were enrolled.
Şermin Eminoğlu +2 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Scientific ReportsIntranasal dexmedetomidine (IN DEX) is being increasingly used for sedation in children undergoing nonpainful diagnostic procedures. Successful procedural sedation facilitates rapid and accurate clinical diagnosis and treatment, thereby improving ...
Huatian Lin +6 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 1999 P(論文)Intravenous sedation with monitored conscious sedation care was applied to cases of dental and minor oral surgical procedures under local anesthesia.
佐藤, 雄季 +17 more
core
„Light sedation" strategy vs. deep sedation in mechanically ventilated patients
Quality in SportBackground. Sedation management is a cornerstone of supportive care for critically ill patients receiving mechanical ventilation. While deep sedation was historically the standard, contemporary practices are shifting toward an "eCASH" model (Comfort and
Julia Kobylińska +3 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source