Results 81 to 90 of about 206,888 (308)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

ネーザルハイフローはプロポフォール鎮静中の換気を改善する健康被験者でのランダム化クロスオーバー研究

, 2020
Objective: Hypoventilation and carbon dioxide (CO2) retention are common during sedation. The current study investigated the ventilation responses to nasal high flow (NHF) during sedation with propofol. Methods: NHF of 30 L/min and 60 L/min with room air
三島, 岳
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Procedural sedation competencies:a review and multidisciplinary international consensus statement on knowledge, skills, training, and credentialing [PDF]

Procedural sedation is practised by a heterogeneous group of practitioners working in a wide array of settings. However, there are currently no accepted standards for the competencies a sedation practitioner should have, the content of sedation training ...
Carlson, Douglas W., Barbi, Egidio, Costa, Luciane R, Babl, Franz E., Irwin, Michael G, Krauss, Baruch S, Costa, Paulo S, Costa, Paulo S., Leroy, Piet L., International Committee for the Advancement of Procedural Sedation, Roback, Mark G., Costa, Luciane R., Absalom, Anthony; id_orcid, Krauss, Baruch S., Babl, Franz E, Roelofse, James, Carlson, Douglas W, Green, Steven M, Mason, Keira P, Leroy, Piet L, Irwin, Michael G., Andolfatto, Gary, Green, Steven M., Mason, Keira P., Roback, Mark G, Absalom, Anthony   +25 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Safety and efficiency of procedural sedation and analgesia (PSA) conducted by medical officers in a level one hospital in Cape Town

, 2011
Objectives: This study aimed to research efficacy and safety of procedural sedation and analgesia (PSA) administered by medical officers (MOs), without formal anaesthetic training, in a South African district hospital.
Wenzel-Smith, Gisela
core  

Early Light Sedation Increased the Duration of Mechanical Ventilation in Patients With Severe Lung Injury

, 2023
application/pdfIntroduction: The international guidelines recommend light sedation management for patients receiving mechanical ventilation. One of the benefits of light sedation management during mechanical ventilation is the preservation of spontaneous
SIMOJO, Nobutake, 大内, 玲, 鳩崎, 千絵, HATOZAKI, Chie, サクラモト, ヒデアキ, オオウチ, アキラ, シモジョウ, ノブタケ, INOUE, Yoshiaki, SAKURAMOTO, Hideaki, イノウエ, ヨシアキ, 下條, 信威, 櫻本, 秀明, ハトザキ, チエ, 井上, 貴昭, OUCHI, Akira   +14 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Protocol-directed sedation versus non-protocol-directed sedation to reduce duration of mechanical ventilation in mechanically ventilated intensive care patients [PDF]

, 2015
Background The sedation needs of critically ill patients have been recognized as a core component of critical care and meeting these is vital to assist recovery and ensure humane treatment.
Aitken, L. M., Aitken, Leanne M., Burmeister, Elizabeth, Mitchell, M., Keogh, Samantha J., Bucknall, T.K., Keogh, S. J., Aitken, Leanne M, Mitchell, Marion, Kent, Bridie, Aitken, Leanne, Burmeister, E., Kent, B., Keogh, Samantha, Keogh, Samantha J, Bucknall, Tracey   +15 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source