Results 81 to 90 of about 190,021 (386)

Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists

Nature Neuroscience, 2015
Do sedatives engage natural sleep pathways? It is usually assumed that anesthetic-induced sedation and loss of righting reflex (LORR) arise by influencing the same circuitry to lesser or greater extents.
Zhe Zhang, V. Ferretti, İlke Güntan, A. Moro, E. Steinberg, Z. Ye, A. Zecharia, Xiao Yu, A. Vyssotski, S. Brickley, R. Yustos, Zoe E Pillidge, Edward C. Harding, W. Wisden, N. Franks   +14 more
semanticscholar   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

In Vivo and In Vitro Biological Evaluation and Molecular Docking Studies of Compounds Isolated from Micromeria biflora (Buch. Ham. ex D.Don) Benth

Molecules, 2022
Micromeria biflora, a traditional medicinal plant, is extensively used for treating various painful conditions, such as nose bleeds, wounds, and sinusitis.
Abdullah S. M. Aljohani, Fahad A. Alhumaydhi, Abdur Rauf, Essam M. Hamad, Umer Rashid   +4 more
doaj   +1 more source

Safety and efficacy of a propofol and ketamine based procedural sedation protocol in children with cerebral palsy undergoing botulinum toxin A injections. [PDF]

, 2019
Background Pediatric patients with cerebral palsy (CP) often undergo intramuscular botulinum toxin (BoNT‐A) injections. These injections can be painful and may require procedural sedation.
Abu-Sultaneh, Samer, Abulebda, Kamal, Louer, Ryan, Lutfi, Riad, McKinney, Renee C.   +4 more
core   +1 more source

Detecting rs‐fMRI Networks in Disorders of Consciousness: Improving Clinical Interpretability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Preserved resting‐state functional MRI (rs‐fMRI) networks are typically observed in Disorders of Consciousness (DOC). Despite the widespread use of rs‐fMRI in DOC, a systematic assessment of networks is needed to improve the interpretability of data in clinical practice.
Jean Paul Medina Carrion, Mario Stanziano, Ludovico D'Incerti, Davide Sattin, Stefania Ferraro, Davide Rossi Sebastiano, Francesca Giulia Magnani, Alice Deruti, Davide Fedeli, Ludovico Minati, Francesca Epifani, Marina Grisoli, Matilde Leonardi, Maria Grazia Bruzzone, Anna Nigri, Cristina Rosazza   +15 more
wiley   +1 more source

ACTION OF BIOLOGICALLY ACTIVE COMPOUNDS - DERIVATIVES OF 4-OXOPYRIMIDINE ON THE BEHAVIOR OF MALE RATS IN THE «OPEN FIELD»

Вестник Северо-Кавказского федерального университета, 2022
The article reveals how when tested in open field was investigated range of activity (sedative, activating and anxiolytic effect) of biologically active compounds - derivatives of 4 - oxo - pyrimidine with acute and chronic administration of a dose 50 mg
Eleonora A. Manveljan, Valeria Y. Sysa, Ivan P. Kodonidi, Edward T. Oganesyan   +3 more
doaj  

Effectiveness of Chloral Hydrate on Brain MRI in Children with Developmental Delay/Intellectual Disability Comparing with Normal Intelligence: Single Tertiary Center Experience

Children, 2021
Neurodiagnostic investigation requirements are expanding for diagnostic and therapeutic purposes in children, especially in those with developmental delay/intellectual disability (DD/ID).
Ja Un Moon, Ji Yoon Han
doaj   +1 more source

The Diagnostic Value of Visual Evoked Potentials in Chronic Disorders of Consciousness

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In chronic disorders of consciousness (DOCs), the distinction between vegetative state/unresponsive wakefulness syndrome (VS/UWS) and minimally conscious state (MCS) is as crucial as it is challenging. Evoked potentials (EPs) and event‐related potentials (ERPs) are helpful, but some limitations prevent their consistent use in the ...
Letizia Clementi, Francesca Giulia Magnani, Filippo Barbadoro, Camilla Ippoliti, Martina Cacciatore, Davide Sattin, Valeria Pingue, Benedetta Cazzulani, Jorge Navarro, Elena Schiaffi, Laura Grigoletti, Cristina Rosazza, Anna Nigri, Matilde Leonardi, Davide Rossi Sebastiano   +14 more
wiley   +1 more source

Manual control analysis of drug effects on driving performance [PDF]

, 1981
The effects of secobarbital, diazepam, alcohol, and marihuana on car-driver transfer functions obtained using a driving simulator were studied. The first three substances, all CNS depressants, reduced gain, crossover frequency, and coherence which ...
Moskowitz, H., Smiley, A., Ziedman, K.
core   +1 more source

The MSA Atrophy Index (MSA‐AI): An Imaging Marker for Diagnosis and Clinical Progression in Multiple System Atrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Reliable biomarkers are essential for tracking disease progression and advancing treatments for multiple system atrophy (MSA). In this study, we propose the MSA Atrophy Index (MSA‐AI), a novel composite volumetric measure to distinguish MSA from related disorders and monitor disease progression. Methods Seventeen participants with an
Paula Trujillo, Kilian Hett, Amy Cooper, Amy E. Brown, Jessica Iregui, Manus J. Donahue, M. Erik Landman, Italo Biaggioni, Margaret Bradbury, Cynthia Wong, David Stamler, Daniel O. Claassen   +11 more
wiley   +1 more source