Results 101 to 110 of about 49,112 (154)

TOXICITY OF SEDATIVE AND HYPNOTIC DRUGS

Lancet, The, 1981
BryanJ. Large, C.J.C. Roberts, E. Shrosbree, T.K. Daneshmend, C.J. Young   +4 more
exaly   +2 more sources

EFFECTS OF SEDATIVE DRUGS ON THE ELECTROENCEPHALOGRAM

American Journal of Psychiatry, 1946
A study is presented of the electroencephalographic effects of small oral doses of the usual sedative drugs (phenobarbital, sodium amytal, nembutal, seconal, paraldehyde, chloral) in 10 normal subjects with normal EEGs. Data on 45 psychiatric patients who had received oral sedation within 24 hours of the electroencephalographic recording are compared ...
openaire   +2 more sources

Sedative drug surveys in coma

Postgraduate Medicine, 1977
Routine blood tests of comatose patients for drugs that depress the CNS are highly desirable, but techniques of analysis are not well standardized and the results do not correlate well with clinical condition. Determining the role of sedative drugs in coma requires a high degree of suspicion and sound clinical judgment.
A E, Walker, G F, Molinari
openaire   +2 more sources

Interactions of CNS Drugs — Hypnotics and Sedatives

Drug Intelligence & Clinical Pharmacy, 1976
The physicochemical properties of the barbiturates and a brief review of microsomal enzyme induction introduces this literature review of the interactions of sedative and hypnotic drugs. Food has been shown to delay absorption of barbiturates; barbiturates, in turn, may interfere with the absorption of griseofulvin, dicumarol, and folic acid ...
S R, Brown, E A, Hartshorn
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Rational Use of Anxiolytic/Sedative Drugs

Drugs, 1983
The benzodiazepines are the most effective, safest, and most widely used antianxiety drugs. As a class of drugs, there are few major differences between the various benzodiazepine derivatives. The main distinguishing features are different plasma half-lives and the presence or absence of pharmacologically active metabolites.
M, Lader, H, Petursson
openaire   +2 more sources

New Type Sedative and Soporific Drug

Science, 1958
Trimethoxybenzoyl-glycine-diethylamide induced in dogs and cats normal sleep without preceding ataxia. A five- to ten-fold increase of the soporific dose resulted in restlessness and disorientation instead of sleep. In man, oral doses of 500 to 1500 mg caused sedation or drowsiness, or both, in half the cases.
G, CRONHEIM, J T, GOURZIS, I M, TOEKES
openaire   +2 more sources

Addiction to nonbarbiturate sedative and tranquilizing drugs

Clinical Pharmacology & Therapeutics, 1964
Increasing numbers of nonbarbiturate sedative drugs are being introduced into medical practice. Despite their nonbarbiturate chemical structure and regardless of designations other than “sedative‐hypnotic,” at least six of the newer depressant drugs can cause states of intoxication and physical dependence that are clinically similar to those induced by
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Sedative-hypnotic drug use and ageing

Archives of Gerontology and Geriatrics, 1983
Behavioural disadvantages associated with the use of sedative-hypnotic drugs in the elderly are considered in relation to four aspects of drug usage reported in the epidemiological literature between 1960 and 1982, viz. (1) the prevalence of drug usage; (2) the type of drug, and the dose used; (3) the typical duration of usage; and (4) the typical ...
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Calcium and Sedative-Hypnotic Drug Actions

1988
Publisher Summary Calcium participates in a large number of neuronal biological processes and its physiological role has been very extensively reviewed in recent years. Laboratories have conducted cellular electrophysiological experiments on the effects of commonly used and abused sedative-hypnotic drugs on central mammalian neurons and have reached ...
P L, Carlen, P H, Wu
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Drug level monitoring: sedative hypnotics

Journal of Chromatography B: Biomedical Sciences and Applications, 1985
Barbiturates and other traditional non-barbiturate sedative hypnotics are still extensively prescribed for the treatment of insomnia. There are a number of situations where identification or quantitative determination of these agents in biological fluids is required.
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