Results 101 to 110 of about 1,433,306 (343)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Derivation of Del180 from sediment core log data\u27 Implications for millennial-scale climate change in the Labrador Sea [PDF]

, 2001
Sediment core logs from six sediment cores in the Labrador Sea show millennial-scale climate variability during the last glacial by recording all Heinrich events and several major Dansgaard-Oeschger cycles.
A. E. Aksu, Andrews, Best, Bond, Bond, Broecker, C. Hillaire-Marcel, Dansgaard, Dowdeswell, F. Rack, Francois, G. Bilodeau, Grootes, Hagelberg, Hamilton, Hamilton, Harris, Heinrich, Hillaire-Marcel, Hillaire-Marcel, Hiscott, Holler, Kissel, L. A. Mayer, Lazier, M. E. Weber, Mayer, Mayer, Mayer, McAyeal, McCave, Mienert, Moros, Oppo, Paillard, Pisias, R. N. Hiscott, Rasmussen, Schön, Shackleton, Stoner, Stoner, Sy, Weber, Weber, Wood   +45 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Development of supply-limited transport due to vertical sorting of a sand-gravel mixture [PDF]

, 2010
If a partially mobile sediment is transported an immobile sediment layer can form below the bedforms. This immobile layer can cause a supply-limitation, i.e. the volume of mobile sediment on top of the layer available for transport becomes limited.
Ribberink, J.S., Spekkers, M.H., Tuijnder, A.P.   +2 more
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Topographic Development History of the Alaska Range [PDF]

, 2013
he overall goal of this project is to use variations in sediment source through time as a proxy for deciphering the uplift history of the Alaska Range (Fig. 1).
Davis, Kailyn
core  

Benthic Foraminiferal response to sea level change in the mixed siliciclastic-carbonate system of southern Ashmore Trough (Gulf of Papua) [PDF]

, 2015
Ashmore Trough in the western Gulf of Papua (GoP) represents an outstanding modern example of a tropical mixed siliciclastic-carbonate depositional system where significant masses of both river-borne silicates and bank-derived neritic carbonates ...
Bentley, Sam J, Carson, Brooke E, Dickens, GR, Droxler, Andre W, Francis, Jason M, Jorry, Stephan J, Leckie, R M, Opdyke, Bradley, Peterson, Larry C   +8 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

N2O production and novel nitric oxide reductases influenced by electron donors during denitrification in rivers

Earth Critical Zone
N2O is a potent greenhouse gas with strong impacts on global warming and ozone layer depletion. The well characterized nitric oxide reductases, cNor and qNor, have known roles in denitrification, while several additional clades—eNor, gNor, nNor, and sNor—
Shengjie Li, Shuo Wang, Yinhao Liao, Guodong Ji   +3 more
doaj   +1 more source

Past, present and future rainfall erosivity in central Europe based on convection-permitting climate simulations [PDF]

Hydrology and Earth System Sciences
Heavy rainfall is the main driver of soil erosion by water, which is a threat to soil and water resources across the globe. As a consequence of climate change, precipitation – especially extreme precipitation – is increasing in a warmer world, leading to
M. Uber, M. Haller, C. Brendel, G. Hillebrand, T. Hoffmann   +4 more
doaj   +1 more source