Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Bioturbation experiments in the Venice Lagoon [PDF]
, 2003 Short experiments (14–21 days) were carried out during autumn 1998 and spring 1999 at one selected site of the Venice Lagoon to measure bioturbation activities and mixing rates, as well as to obtain quantitative information on benthos functionality ...
Bellucci, Luca Giorgio +4 more
core +5 more sources
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Investigation of Metal and Organic Contaminant Distributions and Sedimentation Rates in Backwater Lakes along the Illinois River [PDF]
, 2008 Systematic sub-sampling of sediment cores in sections of uniform thickness is necessary in order to evaluate historic changes in sediment quality, to determine the vertical extent of contamination, and to measure sedimentation rates.
Cahill, Richard A. +2 more
core
Desirable Host Plant Qualities in Wild Rice \u3ci\u3e(Zizania Palustris)\u3c/i\u3e for Infestation by the Rice Worm \u3ci\u3eApamea Apamiformis\u3c/i\u3e (Lepidoptera: Noctuidae) [PDF]
, 2018 The rate at which an insect infests hosts by ovipositioning and/or subsequent growth of larvae often depends on specific desirable host plant qualities.
Dahlberg, Nathan B, Pastor, John
core +2 more sources
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Past, present and future rainfall erosivity in central Europe based on convection-permitting climate simulations [PDF]
Hydrology and Earth System SciencesHeavy rainfall is the main driver of soil erosion by water, which is a threat to soil and water resources across the globe. As a consequence of climate change, precipitation – especially extreme precipitation – is increasing in a warmer world, leading to
M. Uber +4 more
doaj +1 more source
Factors affecting colour and cloud stability in a wildberry herbal drink : a thesis presented in partial fulfilment of the requirements for the degree of M. Tech. in Food Science at Massey University, Albany, New Zealand [PDF]
, 2001 An investigation was undertaken into the stability of the natural colour, from anthocyanins, and cloud in a Wildberry Herbal fruit drink. The fruit drinks consisted of cloudy apple and berry fruit juice with natural herb extracts and flavours.
Evans, John R
core
Mechanical Properties Of Sediment Determine Burrowing Success And Influence Distribution Of Two Lugworm Species [PDF]
, 2017 We apply new perspectives on how organisms burrow by examining the association of in situ variation in sediment mechanical properties with burrowing ability and species distribution of two sympatric lugworms, Abarenicola pacifica and Abarenicola ...
Crane, R. L., Merz, Rachel
core +3 more sources
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source