Results 101 to 110 of about 1,803,074 (391)

Investigation of Metal and Organic Contaminant Distributions and Sedimentation Rates in Backwater Lakes along the Illinois River [PDF]

, 2008
Systematic sub-sampling of sediment cores in sections of uniform thickness is necessary in order to evaluate historic changes in sediment quality, to determine the vertical extent of contamination, and to measure sedimentation rates.
Cahill, Richard A., Salmon, Gary L., Slowikowski, James A.   +2 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A review of reservoir carbon Cycling: Key Processes, influencing factors and research methods

Ecological Indicators
Based on the focus on the role of reservoirs as carbon sources and sinks, this article explores their impact on the global carbon cycle. Reservoirs, which are “artificial lakes” created by human activities in rivers, are reviewed in terms of the key ...
Chunhui Li, Yihan Wang, Yujun Yi, Xuan Wang, Celso Augusto Guimarães Santos, Qiang Liu   +5 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Borneo coral reefs subject to high sediment loads show evidence of resilience to various environmental stressors [PDF]

, 2019
For reefs in South East Asia the synergistic effects of rapid land development, insufficient environmental policies and a lack of enforcement has led to poor water quality and compromised coral health from increased sediment and pollution.
Braoun, Christina, Browne, Nicola, McIlwain, Jennifer, Nagarajan, Ramasamy, Zinke, Jens   +4 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Bedform dimensions under supply limited conditions [PDF]

, 2008
The volume of mobile sediment on the river bed is the primary control on the dimensions of the bed forms that develop. If an unlimited supply of sediment is available the bed form dimensions which develop are determined by the water depth, the flow ...
Ribberink, J.S., Tuijnder, A.P.
core   +1 more source

Use of axial tomography to follow temporal changes of benthic communities in an unstable sedimentary environment (Baie des Ha! Ha!, Saguenay Fjord) [PDF]

, 2003
In the upper layer of the sediment column, organic matter recycling is greatly influenced by bioturbation. However, there are many physical changes in the nature of the sediment that may disturb benthic communities and create a biogeochemical imbalance ...
Aller, Aller, Aller, Aller, Aller, Aller, Berger, Bernard Long, Boespflug, Boespflug, Bray, Canfield, Clarke, Coleman, Crémer, de Montety, Deflandre, Desrosiers, du Berger, Duliu, Emilien Pelletier, Emma Michaud, Franck Gilbert, François, Gage, Gaston Desrosiers, Georges Stora, Gilbert, Gérino, Gérino, Hounsfield, Hulthe, Jacques Locat, Jean-François Crémer, Jones, Kantzas, Kenter, Krantzberg, Kristensen, Kuehl, Lapointe, Laure de Montety, Ligier, Locat, Maurice, Michaud, Mucci, Nerhing, Orsi, Pearson, Pearson, Pelletier, Pelletier, Prena, Rhoads, Rhoads, Rhoads, Rhoads, Rhoads, Risk, Schafer, Sorensen, Stora, Thistle, Tita, Urgelès, Wellington, Yeo, Yu, Zajac, Zar   +70 more
core   +4 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Hydrological factors influencing sediment concentration fluctuations in small drainage basins [PDF]

, 1971
Although sediment concentrations measured in two contrasting streams in East Yorkshire fluctuate in response to similar hydrological factors, the effectiveness of these factors reflects the environmental characteristics of the drainage basins ...
Imeson, A.C.
core   +1 more source