Results 31 to 40 of about 163,364 (267)

Deficiency and excess of groundwater iodine and their health associations

Nature Communications, 2022
Both iodine deficiency and excess could cause thyroid disorders. By creating a national map of groundwater iodine throughout China, the authors reveal the spatial responses of diverse health risks to iodine in continental groundwater.
Ruoqi Ma, Mingquan Yan, Peng Han, Ting Wang, Bin Li, Shungui Zhou, Tong Zheng, Yandi Hu, Alistair G. L. Borthwick, Chunmiao Zheng, Jinren Ni   +10 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Climate change and human activities amplify runoff variability risks in lower reaches of large rivers

Communications Earth & Environment
The contributions of climate change and human activities to runoff variation have been examined in multiple individual catchments, but upstream-downstream interaction relationships remain underexplored.
Ju Gao, Chunhui Li, Xiong Zhou, Yujun Yi, Xuan Wang, Qiang Liu   +5 more
doaj   +1 more source

Cross-Medium Control of Water and Soil Environmental Pollution in Watershed

中国工程科学, 2022
Pollutants have complex source-sink relationships in water and soil environments at a catchment scale, and the transformation of pollutants in water and soil environments is primarily controlled by various water-soil interface processes.
Xia Xinghui , Pei Yuansheng , Wang Gongqin   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Effects of typical artificial reefs on hydrodynamic characteristics and carbon sequestration potential in the offshore of Juehua Island, Bohai Sea

Frontiers in Environmental Science, 2022
The ocean system provides abundant food resources and suitable habitats for numerous animal and plant species. However, the ecological health of the ocean system has deteriorated due to intensified human activities over the past decades.
Anping Shu, Ziru Zhang, Le Wang, Tao Sun, Wei Yang, Jiapin Zhu, Jiping Qin, Fuyang Zhu   +7 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Dynamics of rainfall, discharge, suspended sediment and micropollutant transport in the Moselle River, Central Europe

Environmental Sciences Europe
Background Heavy rainfall causes not only high water levels and discharge but can also lead to the mobilization of sediments and pollutants to rivers. In contrast, droughts with low discharge can impair water quality due to minimized dilution.
Magdalena Uber, Liza-Marie Beckers, Simon Terweh, Peer Helmke, Thomas Hoffmann   +4 more
doaj   +1 more source