Results 71 to 80 of about 1,154,828 (344)

Evaluation of the utility of sediment data in NASQAN (National Stream Quality Accounting Network) [PDF]

, 1983
Monthly suspended sediment discharge measurements, made by the USGS as part of the National Stream Quality Accounting Network (NASQAN), are analysed to assess the adequacy in terms of spatial coverage, temporal sampling frequency, accuracy of ...
Brooks, Norman H., Koh, Robert C. Y., Taylor, Brent D., Vanoni, Vito A.   +3 more
core  

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Denitrification mechanism in oxygen-rich aquatic environments through long-distance electron transfer

npj Clean Water, 2022
The lack of electron donors in oxygen-rich aquatic environments limits the ability of natural denitrification to remove excess nitrate, leading to eutrophication of aquatic ecosystems. Herein, we demonstrate that electron-rich substances in river or lake
Ming-Zhi Wei, Jin-Wei Liu, Qin-Zheng Yang, An Xue, Hao Wu, Jin-Ren Ni, Lea R. Winter, Menachem Elimelech, Hua-Zhang Zhao   +8 more
doaj   +1 more source

Topographic Development History of the Alaska Range [PDF]

, 2014
The overall goal of this project is to use variations in sediment source through time as a proxy for deciphering the uplift history of the Alaska Range (Fig. 1).
Davis, Kailyn N.
core  

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Sediment structure and physicochemical changes following tidal inundation at a large open coast managed realignment site [PDF]

, 2018
Managed realignment (MR) schemes are being implemented to compensate for the loss of intertidal saltmarsh habitats by breaching flood defences and inundating the formerly defended coastal hinterland.
Andrew B. Cundy, Auxtero, Bergen, Berrow, Beven, Bone, Burton, Cnudde, Cochran, Cope, Costanza, Crooks, Crooks, Croudace, Cundy, Cundy, Cundy, Cundy, Dale, Dale, Dale, David J. Nash, Davy, Doherty, Doody, Elliott, Environment Agency, Erfanzadeh, Esteves, European Parliament and the Council of the European Commission, Foster, French, Hazelden, Heidi M. Burgess, Howe, Hvorslev, Ian W. Croudace, Johnston, Jonathan Dale, Kate L. Spencer, Ketcham, Koretsky, Krawiec, Luther, Marani, Mazik, Miller, Moller, Mossman, Odgaard, Pearce, Polder, Reid, Rowell, Rupprecht, Shennan, Shennan, Simon J. Carr, Spencer, Spencer, Spencer, Tempest, Violante, Vogel, Vranken, Watts, Wilson, Wolanski, Zwolsman   +68 more
core   +3 more sources

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Bedform dimensions under supply limited conditions [PDF]

, 2008
The volume of mobile sediment on the river bed is the primary control on the dimensions of the bed forms that develop. If an unlimited supply of sediment is available the bed form dimensions which develop are determined by the water depth, the flow ...
Ribberink, J.S., Tuijnder, A.P.
core   +1 more source

Sustainable rice cultivation in the deep flooded zones of the Vietnamese Mekong Delta [PDF]

, 2017
This paper explains how the management of the full-dyke system in the deep flooded zones of the Vietnamese Mekong Delta affects rice cultivation, and outlines how alternative dyke management strategies could offer more sustainable adaptations in the face
Aalto, Rolf, Chapman, Alexander, Darby, Stephen, Hackney, Christopher, Leyland, Julian, Nicholas, Andrew, Parsons, Daniel, Pham, Thanh Vu, Tompkins, Emma, Van, Pham Dang Tri   +9 more
core   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source