Results 71 to 80 of about 163,364 (267)

Hydrological changes in the Upper Yellow River under the impact of upstream cascade reservoirs over the past 70 years

Journal of Hydrology: Regional Studies
Study region: The Upper Yellow River Basin (UYRB), China. Study focus: In this study, a variety of mathematical statistical methods, the Indicators of Hydrologic Alteration—Range of Variability (IHA-RVA) method, and the newly proposed Flow Surplus ...
Jing Hu, Xiong Zhou, Yujun Yi, Chunhui Li, Xuan Wang, Qiang Liu, Jiansu Mao   +6 more
doaj   +1 more source

Impact on Dongting Lake channel caused by the change of flow and sediment environment after Three Gorges Project impoundment

Shui kexue jinzhan, 2015
The change of river-lake relation is one of the most important factors affecting the flow and sediment environment in the Dongting Lake area. This has a great influence on the safety and development of lake shipping.
ZHANG Ming, FENG Xiaoxiang, LIU Zhe, LI Weijuan   +3 more
doaj   +1 more source

Sedimentation of Reservoirs [PDF]

, 2013
S waves are seismic body waves meaning they travel through the Earth's interior. Their velocity is slower thant that of P waves, and they are normally the second major phase to be observed on a seismorgram, and are therefore also referred to as secondary waves.
openaire   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Anchored atomic Ru-O4 architecture enables ultra-effective Fe(VI) activation via avoiding Fe(VI) self-decay for water purification

Nature Communications
Ferrate (Fe(VI)) is a prospective green oxidant owing to producing highly reactive Fe(IV)/Fe(V) for micropollutant degradation. However, the performance is significantly compromised by the severe side reaction of Fe(VI) self-decay with H2O, generating ...
Yundan Chen, Xiaofei Ge, Jun Li, Zishuai Bill Zhang, Zhenshan Li   +4 more
doaj   +1 more source