Results 71 to 80 of about 584,671 (296)

Water ecological health evaluation of urban river: a case study of Zaogang River, China

Frontiers in Ecology and Evolution
The ecological health of urban rivers serves as a critical indicator of the overall health of urban ecosystems. The water ecological health status of the Zaogang River in Changzhou City was evaluated; nine sections of the river and the Old Zaogang River ...
Jiaqi Zhang, Jiaqi Xiang, Qiwen Ma, Chunhui Li, Xiangen Xu   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Spontaneous enhancement of nitrate assimilation facilitates the adaptation of anaerobic microbiome to hyperosmotic stress by promoting osmoprotectants synthesis

Water Research X
The biotransformation of nitrate (NO3−-N), one of the main reactive nitrogen (N) types produced by human activities, is profoundly changing global climate and biodiversity.
Fei Han, Yiting Guo, Shuhui Zhang, Mengru Zhang, Chuanfu Zhao, Wenhao Zhang, Qinyang Li, Weizhi Zhou   +7 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Effects of deposit-feeding bivalve (Macomona liliana) density on intertidal sediment stability [PDF]

, 2004
Effects of macrofaunal feeding and bioturbation on intertidal sediment stability (u*crit) were investigated by manipulating density (0-3 x ambient) of the facultative deposit-feeding wedge shell (Macomona liliana) on the Tuapiro sandflat in Tauranga ...
Lelieveld, S. D., Pilditch, Conrad A., S. D. Lelieveld, Green, Malcolm O., C. A. Pilditch, M. O. Green   +5 more
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Identifying sediment sources in the tees catchment [PDF]

, 2003
The main objective of this research is to identify the sources of suspended sediments in the River Tees. Earlier work in the Tees has focused on the extent of heavy metal concentrations in the river sediments as a result of mining m the upper catchment ...
Nelson, Tracy Jane
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source