Results 31 to 40 of about 19,866 (262)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Sediment yields from small, steep coastal watersheds of California

Journal of Hydrology: Regional Studies, 2015
Study region: Coastal watersheds of southern California, United States. Study focus: We sought to better understand the rates and variability of suspended-sediment discharge from small coastal watersheds (
Jonathan A. Warrick, John M. Melack, Blair M. Goodridge   +2 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Impact of climate change and anthropogenic activities on stream flow and sediment discharge in the Wei River basin, China [PDF]

Hydrology and Earth System Sciences, 2013
Reduced stream flow and increased sediment discharge are a major concern in the Yellow River basin of China, which supplies water for agriculture, industry and the growing populations located along the river. Similar concerns exist in the Wei River basin,
P. Gao, V. Geissen, C. J. Ritsema, X.-M. Mu, F. Wang   +4 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The Effects of Climate and Anthropogenic Activity on Hydrologic Features in Yanhe River

Advances in Meteorology, 2016
This paper aims to analyze the effects of precipitation and anthropogenic activity on hydrologic features in Yanhe River so as to provide support for regional water management and evaluation of water and soil conservation measures.
Yang Cheng, Hongming He, Nannan Cheng, Wenming He   +3 more
doaj   +1 more source

Trajectories of Physical Function in Canadian Children With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective We describe trajectories of physical function in children newly diagnosed with juvenile idiopathic arthritis (JIA) and identify trajectories with persisting functional impairments and associated baseline characteristics. Methods We included patients enrolled in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry ...
Clare Cunningham, Meghan McPherson, Lillian Lim, Roberta A. Berard, Matthew Berkowitz, Jean‐Philippe Proulx‐Gauthier, Brian M. Feldman, Nicole Johnson, Dax G. Rumsey, Heinrike Schmeling, Lori B. Tucker, Thomas Loughin, Kristin M. Houghton, Jaime Guzman, for the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry Investigators, David A. Cabral, Gaëlle Chédeville, Ciarán M. Duffy, Kerstin Gerhold, Jaime Guzman, Linda Hiraki, Adam M. Huber, Heinrike Schmeling, Natalie J. Shiff, Lori B. Tucker, Julie Barsalou, Daniah Basodan, Michelle Batthish, Roberta A. Berard, Nicholas Blanchette, Gilles Boire, Roxana Bolaria, Alessandra Bruns, David A. Cabral, Sarah Campillo, Tania Cellucci, Mercedes Chan, Gaëlle Chédeville, Amieleena Chhabra, Julie Couture, Paul Dancey, Jean‐Jacques De Bruycker, Erkan Demirkaya, Muhammed Dhalla, Ciarán M. Duffy, Talal El Tal, Tommy Gerschman, Jaime Guzman, Liane Heale, Julie Herrington, Kristin M. Houghton, Adan M. Huber, Andrea Human, Nicole Johnson, Roman Jurencak, Bianca Lang, Claire LeBlanc, Lillian Lim, Lily S. H. Lim, Nadia Luca, Jeanine McColl, Tara McGrath, Tamara McMillan, Megan McPherson, Paivi Miettunen, Kimberly Morishita, Honyan Ng, Jonathan Park, Jean‐Philippe Proulx‐Gauthier, Johannes Roth, Evelyn Rozenblyum, Dax G. Rumsey, Heinrike Schmeling, Rosie Scuccimarri, Gordon Soon, Rebeka Stevenson, Elizabeth Stringer, Herman Tam, Lori B. Tucker, Marinka Twilt, Ruud H. J. Verstegen, Karen Watanabe Duffy   +81 more
wiley   +1 more source

Sediment–flow interactions at channel confluences: A flume study

Advances in Mechanical Engineering, 2015
Sediment transport and bed morphology at channel confluences with different confluence angles and discharge ratios are analyzed through a series of flume experiments.
Tonghuan Liu, Beilin Fan, Jinyou Lu
doaj   +1 more source

Sediment Dynamics Observed in the Jhoushuei River and Adjacent Coastal Zone in Taiwan Strait [PDF]

Oceanography, 2011
Taiwan's rugged, mountainous terrain, a result of active tectonics, and its monsoonal climate create conditions that produce the greatest sediment yield compared to all land surfaces on Earth. It is estimated that, on average, Taiwanese rivers discharge ~
Hwa Chien, Wen-Son Chiang, Shuh-Ji Kao, James T. Liu, Kon-Kee Liu, Philip L.-F. Liu   +5 more
doaj  

On the Issue of Calculation of the Suspended Sediment Load Discharge

Water sector of Russia: problems, technologies, management, 2020
The article deals with the questions of the contribution of suspended sediment in the processes of formation of the channel, and includes several formulas of suspended sediment discharge calculation and the results of calculations by these formulas. An analytical formula of sediments, in which the absolute exponent of the degree of arguments is equal ...
openaire   +2 more sources