Results 61 to 70 of about 899 (247)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Post‐Wildfire Sediment Fluxes and Turbidity Plumes in a Coastal‐Draining Watershed

Earth and Space Science
Coastal watersheds impacted by wildfires experience higher erosion resulting in increased sediment delivery to the ocean that alters limiting factors (i.e., light) for marine organisms.
Amanda M. Lopez, Tesfa W. Meshesha, Christine M. Lee, Ibrahim N. Mohammed, Erin L. Hestir, Thomas C. Harmon, Dulcinea M. Avouris   +6 more
doaj   +1 more source

River system sediment rating curve parameter estimation via integrated models

International Journal of Sediment Research
Continuous water and sediment flow monitoring across river cross sections is essential for the management of flood- and sediment-related problems in watersheds.
Tushar Khankhoje, Samrat Boro, Parthasarathi Choudhury   +2 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Hydroclimatic control on suspended sediment dynamics of a regulated Alpine catchment: a conceptual approach [PDF]

Hydrology and Earth System Sciences, 2018
We analyse the control of hydroclimatic factors on suspended sediment concentration (SSC) in Alpine catchments by differentiating among the potential contributions of erosion and suspended sediment transport driven by erosive rainfall, defined as ...
A. Costa, D. Anghileri, P. Molnar
doaj   +1 more source

Suspended Sediment Rating Curves for Heterogeneous Karst Watersheds

Water Resources Research
Abstract Water‐sediment relationships are complicated in karst areas of southwest China due to regional extreme climate, special geological conditions, shallow soil layer, heterogeneous geomorphology and landscape.
Shuning Li, Xingxiu Yu, Zhenwei Li, Xianli Xu, Kelin Wang   +4 more
openaire   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source