Results 51 to 60 of about 78,796 (264)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Sediment Characteristics and Sources Tracing of Warping Dam in Sanggan River Basin

Shuitu Baochi Xuebao
[Objective] This study intends to explore the main source of sediment and the evolution of erosion and sediment yield in Sanggan River Basin. [Methods] A typical warping dam in Gaoqiang Township, Yangyuan County was selected as the research object.
XIE Xiaojian, SU Zheng’an, ZHOU Tao, WANG Lijuan, ZHOU Ling   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Sediment source determination comparing rare earth element tracing and composite fingerprinting approaches on hillslopes

International Soil and Water Conservation Research
Both the rare earth element (REE) tracing and the composite fingerprinting approaches are valuable for sediment source identification. However, few studies have compared the accuracy of sediment source determination based on these two approaches ...
Jiaqiong Zhang, Minfeng Yin, Kaizu Wu, Ruru Bai, Yueting Shang, Mingyi Yang, Yingge Xie   +6 more
doaj   +1 more source

Source to sink reconstruction of a Holocene Fjord‐infill: Depositional patterns, suspended sediment yields, wind‐induced circulation patterns and trapping efficiency for Lake Strynevatnet, inner Nordfjord, Norway

The Depositional Record, 2020
This paper reconstructs the sedimentation volumes and patterns, suspended sediment yields, wind‐induced circulation patterns and sediment trapping efficiency of Lake Strynevatnet, western Norway as an integrated source to sink system.
Joep E. A. Storms, Achim A. Beylich, Louise Hansen, Nicolas Waldmann   +3 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Temporal sediment source tracing during storm events in the black soil region, Northeast China

International Soil and Water Conservation Research
Sediment fingerprinting technology is widely used to differentiate sediment sources. However, despite its long-recognized benefits, there it has been seldom applied to assess the variability of sediment sources during storm events.
Lin Su, Donghao Huang, Lili Zhou, Chengjiu Guo, Baoyong Liu   +4 more
doaj   +1 more source

Hydraulic Optimization of River Sub-Channels for Sediment Reduction and Pump Protection under Low Discharge Conditions: A Literature Review [PDF]

EPJ Web of Conferences
Sediment-laden flow remains a major source of hydraulic efficiency reduction, deposition, clogging and wear in pumps, intakes, forebays and turbomachinery, especially during low flow conditions, in which uneven flow structures and local sediment ...
Abdulrazzaq Noor Ali, Hilo Ali N.
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source