Results 61 to 70 of about 78,796 (264)

Simulation Model for Collaborative Decision Making on Sediment Source Reduction in an Intensively Managed Watershed

Water Resources Research, 2019
We developed a watershed sediment source and delivery model for use in evaluating conservation trade‐offs in southern Minnesota, where sediment loading has been identified as a priority and there is substantial public investment in cleaner water.
Se Jong Cho, Peter R. Wilcock, Patrick Belmont, Karen B. Gran, Benjamin F. Hobbs   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Reconnaissance study of watershed and cave sediment sources discharging from a karst spring, Iowa

Agrosystems, Geosciences & Environment
Springs discharging from karst landscapes provide sustainable flows to natural ecosystems and support productive fish hatcheries but sediment discharging from springs threatens the long‐term sustainability of hatcheries.
Keith E. Schilling, Joseph Honings, Thomas Doyle, Calvin Wolter, David Peate   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Analysis of runoff and sediment evolution and attribution in the source regions of the Yangtze and Yellow Rivers

Journal of Hydrology: Regional Studies
Study region: The source regions of the Yangtze and Yellow Rivers Study focus: The purpose of this study is to analyze the latest evolution trends of runoff and sediment load in the source areas of the Yangtze and Yellow Rivers, quantitatively attribute ...
Shu Xu, Tianling Qin, Xizhi Lv, Jie Lu, Jianming Feng, Haoyue Gao, Hanxiao Liu, Yuhui Yang   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Fluvial and Eolian Sediment Mixing During Changing Climate Conditions Recorded in Holocene Andean Foreland Deposits From Argentina (31–33°S)

Frontiers in Earth Science, 2019
Continental drainage systems archive complex records of rock uplift, source area relief, precipitation, glaciation, and carbon cyclicity driven largely by tectonics and climate.
Tomas N. Capaldi, Sarah W. M. George, Jaime A. Hirtz, Brian K. Horton, Brian K. Horton, Daniel F. Stockli   +5 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Study on Soil Erosion Monitoring Using Sediment Budget

Shuitu baochi yanjiu, 2004
The method of soil erosion monitoring assisted by sediment budget is proposed.It is analyzed that the coupling relationship between the soil erosion monitoring and the three parts of sediment budget includes the sediment source,sediment storage and ...
FAN Hao-ming~
doaj