Results 101 to 110 of about 1,929,099 (294)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Impact of urbanization on the sediment yield in tropical watershed using temporal land-use changes and a GIS-based model

Journal of Water and Land Development, 2017
Abundant rainfall areas promote sediment yield at both sub-watershed and watershed scale due to soil erosion and increase siltation of river channel, but it can be curtailed through planned urbanization.
Bello Al-Amin D., Hashim Noor B., Haniffah Ridza M.   +2 more
doaj   +1 more source

Evaluating the impact of land use and land cover changes on sediment yield dynamics in the upper Awash basin, Ethiopia the case of Koka reservoir. [PDF]

Heliyon, 2023
Bihonegn BG, Awoke AG.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Holocene sediment dynamics in an upland temperate lake catchment : climatic and land-use impacts. [PDF]

, 2009
Accelerated erosion and transport of fine sediment from upland temperate catchments can reflect increased erosivity and/or erodibility, due in turn to climatic and/or human forcing.
Hatfield, Robert G., Maher, Barbara A.
core   +2 more sources

Runoff and sediment yield characteristics on hillslopes with different soil types and their main influencing factors

Shuitu baochi yanjiu
ObjectiveThe study aims to investigate differences in sediment and runoff yield characteristics on hillslopes with various soil types and their primary influencing factors， providing insights into erosion mechanisms across various soils.MethodsSimulated ...
Liang Haoming, Zhang Jiaqiong, Yin Minfeng, Li Tongchuan, Bai Ruru, Shang Yueting, Dang Zhen   +6 more
doaj  

Sediment yield estimation and evaluating the best management practices in Nashe watershed, Blue Nile Basin, Ethiopia. [PDF]

Environ Monit Assess, 2023
Leta MK, Waseem M, Rehman K, Tränckner J.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Exploring fine sediment dynamics and the uncertainties associated with sediment fingerprinting in the Nene river basin, UK [PDF]

To comply with the European Union Water Framework Directive (2000), National Governments are required to achieve good chemical and ecological status of freshwater bodies.
Pulley, Simon
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source