Results 91 to 100 of about 34,260 (258)

Evaluating the impact of land use and land cover changes on sediment yield dynamics in the upper Awash basin, Ethiopia the case of Koka reservoir. [PDF]

Heliyon, 2023
Bihonegn BG, Awoke AG.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Sediment yield estimation and evaluating the best management practices in Nashe watershed, Blue Nile Basin, Ethiopia. [PDF]

Environ Monit Assess, 2023
Leta MK, Waseem M, Rehman K, Tränckner J.   +3 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Calibration, Validation and Performance Evaluation of Swat Model for Sediment Yield Modelling in Megech Reservoir Catchment, Ethiopia

Journal of Environmental Geography, 2019
Intensive agricultural practice in Ethiopian highlands results in increasing rates of soil erosion and reservoir sedimentation. The estimation of sediment yield and prediction of the spatial distribution of soil erosion on the upper Megech reservoir ...
Assfaw Abebe Tarko
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Soil erosion characteristics on grassland slope under light grazing and closed grazing in Xiazangtan landslide

Shuiwen dizhi gongcheng dizhi
The giant landslide distribution area in the upper reaches of the Yellow River faces severe ecological and environmental challenges, including grassland degradation and slope soil erosion.
Peihao ZHANG, Guangyan XING, Xiasong HU, Jimei ZHAO, Changyi LIU, Zhe ZHOU, Lei YUE, Shuaifei LI   +7 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Simulation runoff and sediment yield in a harvested forest (Case study: Zailakirood Basin, northern Iran) [PDF]

مجله جنگل ایران, 2019
In this research, the impacts of forest operation and road construction on runoff and sediment yield were investigated in Zailakirood Basin. As there was only one hydrometric station and sediment measurement at the outlet of the basin, estimation of ...
Adel Kazemi Talkouyee, Meghdad Jourgholami, Karim Abbaspour, Jahangir Feghhi   +3 more
doaj  

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source