Results 71 to 80 of about 35,302 (256)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Ecological IndicatorsSediment connectivity is a crucial factor in determining the mode, efficiency, and scale of sediment transport. However, changes in sediment connectivity and their impact on sediment transport in southern Jiangxi Province, China, remain unclear ...
Fei Sheng +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Research on Impacts of Different Slope Gradientson Runoff and Sediment Yield in Dabie Mountains
Renmin Zhujiang, 2020 Dabie Mountains is a national key prevention and protection area for water and soilloss. Aiming at the problem of soil and water loss in Dabie Mountains, and taking the field flowplot of the soil and water conservation test station in Huoshan County as ...
YIN Jinfan +6 more
doaj
Soil erosion, sediment yield and sedimentation of reservoir: a review [PDF]
Modeling Earth Systems and Environment, 2016 Sedimentation is an important parameter to assess the life of a reservoir. Seventy-eight years ago, Cook was the first to identify mathematically, the three major factors affecting soil erosion in the catchment of a reservoir. As sedimentation is dependent on sediment yield and sediment yield depends on soil erosion, it is required to predict all three
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Sensors, 2008 The geo-spatial interface of the WEPP model called GeoWEPP uses digital geo-referenced information integrated with the most common GIS tools to predict sedimentyield and runoff.
Muzaffer Cetiner +4 more
doaj