Results 51 to 60 of about 1,929,099 (294)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Statistical Analysis and Modeling of Suspended Sediment Yield Dependence on Environmental Conditions
, 2023 This paper describes the modelling of suspended sediment yield in a plains region in the European part of Russia (EPR) and its prediction for ungauged catchments.
Svetlana Mukharamova, Oleg Yermolaev
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Impact of coarse sediment supply from hillslopes to the channel in runoff-dominated, dryland fluvial systems [PDF]
, 2014 Sediment supply from hillslopes to channels is an important control on basin functioning and evolution. However, current theoretical frameworks do not adequately consider processes of runoff-driven hillslope sediment supply, which affect river channels ...
Michaelides, Katerina +3 more
core +1 more source
Land, 2021 Soil erosion has become the dominant environmental issue endangering sustainable development in agriculture and the ecosystem on the Loess Plateau. Determination of watershed soil erosion rates and sediment yields is essential for reasonable utilization ...
Fabing Xie +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Shuitu baochi yanjiu, 2006 3sub-watersheds in the north of Jinghe basin were selected as study areas.Based on the runoff and sediment data of 3 hydrological stations and the precipitation data,classified MODIS image data,all of these were analyzed runoff and sediment variation of ...
WANG Xi-zhi~1 +4 more
doaj
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Lateral sediment sources and knickzones as controls on spatio-temporal variations of sediment transport in an Alpine river [PDF]
, 2013 Modern mixed alluvial-bedrock channels in mountainous areas provide natural laboratories for understanding the time scales at which coarse-grained material has been entrained and transported from their sources to the adjacent sedimentary sink, where ...
Norton, Kevin P. +8 more
core +2 more sources