Results 51 to 60 of about 35,302 (256)

Soil Erosion, Sediment Yield, and Runoff Modeling of the Megech Watershed Using the GeoWEPP Model

Hydrology, 2022
Modeling soil erosion, sediment yield, and runoff are crucial for managing reservoir capacity, water quality, and watershed soil productivity. However, the monitoring and modeling of soil erosion and sedimentation rates in developing countries such as ...
Mulugeta Admas, Assefa M. Melesse, Brook Abate, Getachew Tegegne   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Impact of land management scenarios on sediment yield in the Gateno sub watershed Ethiopia using the InVEST model

Discover Environment
Sediment yield poses significant challenges to agricultural productivity, water availability, and watershed sustainability in the Ethiopian highlands.
Wasie Asmamaw Ashagrie, Getasew Daru Tariku, Sinkie Alemu Kebede, Assefa Deginew Dessie, Moges Tadesse Gedamu, Anteneh Asfaw Ayalew, Yishak Yiferu Teklegiorgis, Birtukan Shege Desalegn, Tazebew Abera Tadesse, Hamid Mekonenn Fante, Tadsual Asfaw Dessie   +10 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Estimation of Sediment Yield in a Small Urban Ungauged Watershed based on the Schaffernak Approach at Sugutamu Watershed, Ciliwung, West Java

International Journal of Technology, 2015
The sediment yield is defined as the amount of sediment discharged by an area for a given period of time. Schaffernak proposed to estimate sediment yield in a watershed based on a sediment duration curve.
Dwita Sutjiningsih, Herr Soeryantono, Evi Anggraheni   +2 more
doaj   +1 more source

Sediment yield at southwest Ethiopia's forest frontier [PDF]

Land Degradation & Development, 2019
AbstractDeforestation is one of the major factors affecting soil erosion in tropical regions but to what extent does the crop growth in deforested areas protect the land from erosion? We evaluated the effect of deforestation on suspended sediment yield at the scale of zero‐order catchments by contrasting five paired small forest and cropland catchments
Henok Kassa, Amaury Frankl, Stefaan Dondeyne, Jean Poesen, Jan Nyssen   +4 more
openaire   +4 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source