Results 61 to 70 of about 1,929,099 (294)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Sediment budget for a North Pennine upland reservoir catchment, UK [PDF]

, 2003
Sediment delivery from upland fluvial systems in the UK is of considerable importance in catchment management. However, scarcity of detailed data on sediment sources, storage and linkages between geomorphic processes inhibits current understanding of ...
Holliday, Victoria Jane
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

SPATIAL AND TEMPORAL DYNAMICS OF FINE FLUVIAL SEDIMENT TRANSFER: IMPLICATIONS FOR MONITORING AND MANAGEMENT OF UPLAND RIVER SYSTEMS [PDF]

, 2013
Although the impacts of changing land use on the magnitude and timing of erosion in lowland catchments are well documented, much less is known about the transfer dynamics of fine sediment through the upland hydrological networks.
PERKS, MATTHEW,THOMAS
core  

Impact of land management scenarios on sediment yield in the Gateno sub watershed Ethiopia using the InVEST model

Discover Environment
Sediment yield poses significant challenges to agricultural productivity, water availability, and watershed sustainability in the Ethiopian highlands.
Wasie Asmamaw Ashagrie, Getasew Daru Tariku, Sinkie Alemu Kebede, Assefa Deginew Dessie, Moges Tadesse Gedamu, Anteneh Asfaw Ayalew, Yishak Yiferu Teklegiorgis, Birtukan Shege Desalegn, Tazebew Abera Tadesse, Hamid Mekonenn Fante, Tadsual Asfaw Dessie   +10 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Dynamics of fluvial fine sediment transfer in the River Esk, North Yorkshire, UK [PDF]

, 2006
A full understanding of the complexities of fluvial suspended sediment dynamics requires a holistic approach. The study presented here addresses fine sediment transfer in the River Esk catchment, which is suffering from the adverse effects of increased ...
Mills, Carolyn
core  

Seasonal Variation of Acid Volatile Sulfide and Simultaneously Extracted Metals in Sediment Cores from the Pearl River Estuary [PDF]

, 2014
The simultaneously extracted metals/acid volatile sulfide (SEM/AVS) method is widely used to estimate the toxicity of metals in sediment. In this study, SEM and AVS concentrations were obtained by the cold-acid purge-and-trap technique during spring ...
Chen, Fanrong, Wu, SJ, Yang, Yongqiang, Wu, Shijun, Yang, YQ, Liu, Jinsong, Zhang, L, Kang, ML, Zhang, Ling, Kang, Mingliang, Chen, FR, Liu, JS   +11 more
core   +1 more source

Sediment yield at southwest Ethiopia's forest frontier [PDF]

Land Degradation & Development, 2019
AbstractDeforestation is one of the major factors affecting soil erosion in tropical regions but to what extent does the crop growth in deforested areas protect the land from erosion? We evaluated the effect of deforestation on suspended sediment yield at the scale of zero‐order catchments by contrasting five paired small forest and cropland catchments
Henok Kassa, Amaury Frankl, Stefaan Dondeyne, Jean Poesen, Jan Nyssen   +4 more
openaire   +4 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source