Results 81 to 90 of about 1,929,099 (294)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Climate Change Impacts on Soil Erosion and Sediment Yield in a Watershed
, 2020 This study analyzed the influence of climate change on sediment yield variation, sediment transport and erosion deposition distribution at the watershed scale.
Samkele S. Tfwala +2 more
core +1 more source
Shuitu baochi yanjiu, 2004 There are a lot of studies on soil erosion and sediment yield models in China and abroad so far,and many soil erosion and sediment yield models have been built up.
YUAN Zai-jian +2 more
doaj
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Effect of Discharge and Slope Gradient on Colluvial Deposits Erosion in Benggang
Shuitu baochi yanjiu, 2014 The colluvial deposits is an important part of Benggang, which has the characteristics of loose texture, high content of coarse particle, large slope gradient and high erosivity.
ZHAO Gan +8 more
doaj
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Effect of Rain Peak Morphology on Runoff and Sediment Yield in Miyun Water Source Reserve in China
, 2019 The research on the impact of rainfall patterns on runoff and sediment yield is still insufficient, especially under natural rainfall conditions. We analyzed the influence of rain peak morphology on runoff and sediment yield based on the data of rainfall,
Fenzhong Wang +3 more
core +1 more source
A cost-effective method to quantify biological surface sediment reworking [PDF]
, 2013 We propose a simple and inexpensive method to determine the rate and pattern of surface sediment reworking by benthic organisms. Unlike many existing methods commonly used in bioturbation studies, which usually require sediment sampling, our approach is ...
De Nadaï-Monoury, Eve +5 more
core +1 more source