Results 51 to 60 of about 201,517 (307)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Sediment yield as a desertification risk indicator [PDF]

Science of The Total Environment, 2011
Soil erosion is often regarded as one of the main processes of desertification. This has led to the use of various desertification indicators that are related to soil erosion. Most of these indicators focus, however, on small spatial units, while little attention has been given to the amount of sediment exported at the catchment scale.
Vanmaercke, Matthias, Poesen, Jean, Maetens, Willem, de Vente, Joris, Verstraeten, Gert   +4 more
openaire   +4 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A spatially distributed model for the dynamic prediction of sediment erosion and transport in mountainous forested watersheds [PDF]

, 2006
Erosion and sediment transport in a temperate forested watershed are predicted with a new sediment model that represents the main sources of sediment generation in forested environments (mass wasting, hillslope erosion, and road surface erosion) within ...
Bowling, Laura C., Doten, Colleen O., Lanini, Jordan S., Lettenmaier, Dennis P., Maurer, Edwin P.   +4 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Soil Erosion, Sediment Yield, and Runoff Modeling of the Megech Watershed Using the GeoWEPP Model

Hydrology, 2022
Modeling soil erosion, sediment yield, and runoff are crucial for managing reservoir capacity, water quality, and watershed soil productivity. However, the monitoring and modeling of soil erosion and sedimentation rates in developing countries such as ...
Mulugeta Admas, Assefa M. Melesse, Brook Abate, Getachew Tegegne   +3 more
doaj   +1 more source

Sediment Yield by Category [PDF]

, 2018
The land use greatly influence water quality on the one supplied by watersheds. Land use changes often increase significantly the sedimentation and nutrient pollution. Human activity can generate as well pollutant concentration rising and heavily affect water treatment cost for urban supply. This map shows the total quantity of sediment moving out of a
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

High-temporal resolution fluvial sediment source fingerprinting with uncertainty: a Bayesian approach [PDF]

, 2014
This contribution addresses two developing areas of sediment fingerprinting research. Specifically, how to improve the temporal resolution of source apportionment estimates whilst minimizing analytical costs and, secondly, how to consistently quantify ...
Acornley, Agency, Bilotta, Blake, Boardman, Buchanan, Collins, Collins, Collins, Collins, Cooper, D'Haen, Dutton, Egozcue, Evans, Evrard, Evrard, Fox, Gellis, Gruszowski, Hancock, Hilton, Hiscock, Hiscock, Hopkins, Horowitz, House, Huisman, Jobbágy, Kim, Krueger, Lefrançois, Legout, Lewis, Martínez-Carreras, Martínez-Carreras, Massoudieh, Matsumoto, Meteorological Office, Motha, Navratil, Olley, Owens, Palmer, Parnell, Parnell, Phillips, Plummer, Poulenard, Poulenard, Pretty, R Development Core Team, Rawlins, Rawlins, Rowan, Russell, Schindler Wildhaber, Sear, Semmens, Slimane, Small, Smith, Smith, Smith, Theuring, Thompson, Thompson, Tremblay, Walling, Walling, Wilkinson, Williams   +71 more
core   +1 more source