Results 61 to 70 of about 175,741 (333)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Recent marine carbonate hardgrounds at Abu Dhabi: towards a better understanding of ‘hidden hardgrounds’ in the geological past

Frontiers in Marine Science
Marine hardgrounds are common features during the Phanerozoic and hold significant sedimentological and economic importance. Intriguingly, previous reports of marine hardgrounds are concentrated in Calcite Seas, despite elevated seawater CaCO3 saturation
Chao Chen, Chao Chen, Hanting Zhong, Hanting Zhong, Xia Wang, Xia Wang, Xia Wang, Meng Ning, Meng Ning, Xinyu Wang, Han Wang, Han Wang, Ruifeng Tang, Mingcai Hou, Mingcai Hou   +14 more
doaj   +1 more source

Rock magnetic and geochemical evidence for authigenic magnetite formation via iron reduction in coal-bearing sediments offshore Shimokita Peninsula, Japan (IODP Site C0020) [PDF]

, 2017
Sediments recovered at Integrated Ocean Drilling Program (IODP) Site C0020, in a fore‐arc basin offshore Shimokita Peninsula, Japan, include numerous coal beds (0.3–7 m thick) that are associated with a transition from a terrestrial to marine ...
Clyde, William C., Johnson, Joel E., Maxbauer, Daniel P., Phillips, Stephen C., Riedinger, Natascha, Setera, Jacob B., Severmann, Silke   +6 more
core   +1 more source

Evidence of late Quaternary environmental change in a continental east Antarctic lake from lacustrine sedimentary pigment distributions [PDF]

, 2005
A sediment core from Progress Lake, one of the oldest lacustrine sequences in East Antarctica, contains distinct zones dating from a previous interglacial (most likely Marine Isotope Stage 5e, c.
Hodgson, D A, Keely, B J, Squier, A H
core   +2 more sources

Heterogeneity of Rheumatoid Arthritis–Associated Interstitial Lung Disease by Longitudinal Forced Vital Capacity Trajectory and Associations With Disease Outcomes

Arthritis Care &Research, EarlyView.
Objective We aimed to identify unique disease trajectories within rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) based on longitudinal forced vital capacity (FVC) values and their associated clinical outcomes. Methods We performed a cohort study of RA‐ILD within the Veterans Health Administration from 1999 to 2021.
Bryant R. England, Yangyuna Yang, Punyasha Roul, Tate M. Johnson, Scott M. Matson, Grant W. Cannon, Brian C. Sauer, Jeffrey R. Curtis, Joshua F. Baker, Ted R. Mikuls   +9 more
wiley   +1 more source

A four stage evolution of the White Channel gravel: Implications for stratigraphy and palaeoclimates [PDF]

, 2014
Although the White Channel gravel (WCG) of the Klondike district, Yukon, contains gold placers which have been exploited for over a century, few sedimentological studies have been undertaken.
Chapman, Robert, Lowther, Robert, Peakall, Jeff, Pound, Matthew   +3 more
core  

Effectiveness and safety of baricitinib for juvenile idiopathic arthritis associated uveitis or chronic anterior antinuclear antibody positive uveitis

Arthritis Care &Research, Accepted Article.
Objectives Evaluate the efficacy and safety of baricitinib in paediatric patients with active JIA‐U or chronic anterior ANA‐positive uveitis, who had an inadequate response to MTX or bDMARDs. Methods JUVE‐BRIGHT was an open‐label, active‐controlled, Phase‐3 multicentre trial which utilized a novel design, including 1:1 randomization to an active ...
Athimalaipet V. Ramanan, Catherine M. Guly, Gabriele Simonini, Stuart Keller, Priyanka Sen, Thorsten Holzkaemper, Joana Araújo, Pierre Quartier   +7 more
wiley   +1 more source

Combining Three Peripheral Blood Biomarkers to Stratify Rheumatoid Arthritis‐Associated Interstitial Lung Disease Risk

Arthritis Care &Research, Accepted Article.
Objective The purpose was to evaluate a biomarker score consisting of MUC5B rs35705950 promoter variant, plasma matrix metalloproteinase (MMP)‐7, and serum anti‐malondialdehyde‐acetaldehyde (anti‐MAA) antibody for RA‐associated interstitial lung disease risk stratification. Methods Using a multicenter cohort of US veterans with RA, we performed a cross‐
Kelsey Coziahr, Austin M. Wheeler, Brent A. Luedders, Michael Duryee, Halie Frideres, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Dana P. Ascherman, Paul A. Monach, Gail S. Kerr, Andreas M. Reimold, Scott M. Matson, Joshua F. Baker, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +16 more
wiley   +1 more source

Paleo-uplift forced regional sedimentary evolution: A case study of the Late Triassic in the southeastern Sichuan Basin, South China

Petroleum
The sedimentary environment of the Upper Triassic in the southeastern Sichuan Basin is obviously controlled by Luzhou paleo-uplift (LPU). However, the influence of paleo-uplift on the sedimentary patterns of the initial stages of this period in the ...
Fangyu He, Qingsong Cheng, Dongtao Zhang, Yubing Ji, Ziying Wang, Tenghui Lu   +5 more
doaj   +1 more source