Results 121 to 130 of about 368,619 (299)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Erythrocyte sedimentation rate as a marker for coronary heart disease

, 2012
Josef YayanDepartment of Internal Medicine, Vinzentius Hospital, Landau, GermanyBackground: Patients with angina pectoris or myocardial infarction frequently present without evidence of cardiac-specific heart enzymes by laboratory analysis or specific ...
Yayan J
core  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Controls on channel morphodynamics in the Yellow River Estuary: Insights from a multi-method assessment under an evolving multi-channel regime

International Journal of Sediment Research
The Yellow River Estuary (YRE) in China has transitioned to a complex multi-channel regime since 2013, making understanding terminal channel morphodynamics crucial for effective water and sediment management.
Yanjie Sun, Xiaolong Song, Haijue Xu, Yuchuan Bai   +3 more
doaj   +1 more source

SEDIMENT MANAGEMENT IN FLOOD CONTROL DAMS [PDF]

Reservoir sedimentation reduces economic value and longevity of flood control dams. Periodic sediment removal allows extension of reservoir life. An optimal control model is developed to evaluate alternative sediment management strategies for flood ...
Pattanapanchai, Maneechit, Shah, Farhed A., Annandale, George   +2 more
core  

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Insights into the impacts of inflow discharge variation on cross-sectional topography in the upper neck area of a laboratory-scale subaerial delta from SWJ–LSTM simulations

International Journal of Sediment Research
Rivers significantly influence delta morphology and sedimentation patterns. However, the dynamic effects of rivers on the upper neck areas of subaerial deltas, which are the complex zones connecting main channels to distributary networks, remain ...
Xiaolong Song, Haijue Xu, Yuchuan Bai
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Calibration and Validation of the Concepts Model for Predicting Gully Erosion and Evaluating Gully Control Measures in the Sub-Humid Highlands of Ethiopia

Blue Nile Journal of Agricultural Research, 2020
The objective of this study was to calibrate and validate the CONCEPTS model for simulating gully expansion and for evaluating the effects of protection measures on gullies in the sub-humid Debre Mawi watershed near Lake Tana, Ethiopia.
Assefa D. Zegeye, Eddy J. Langendoen
doaj  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source