Results 101 to 110 of about 377,749 (305)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Frontiers in Marine ScienceThis study employed physical model experiments based on a practical engineering project to investigate the wave attenuation performance of a floating breakwater under oblique irregular wave and wave–current interaction conditions.
Hang Xu +9 more
doaj +1 more source
Geotechnical Characterization and Sedimentation Behavior of Laterite Slurries
, 2004 : Laterites are the main source of economic metals such as nickel and cobalt. In many parts of the globe, these metals are extracted using the pressure acid leach operation. An efficient rate of sedimentation and a high solids content of the material are
Scott, J. D., Chalaturnyk, R., Azam, S.
core +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
An Estimation Method of River Dry Runoff Alteration after Upper New Reservoirs Storage
Applied SciencesThe impact of reservoirs on downstream river hydrological characteristics is always a focal point in relevant studies exploring the relationship between rivers and dams. Anticipating river runoff patterns following the construction of new dams is crucial
Zuoqiang Chen +5 more
doaj +1 more source
SEDIMENT MANAGEMENT IN FLOOD CONTROL DAMS [PDF]
Reservoir sedimentation reduces economic value and longevity of flood control dams. Periodic sediment removal allows extension of reservoir life. An optimal control model is developed to evaluate alternative sediment management strategies for flood ...
Pattanapanchai, Maneechit +2 more
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Shui kexue jinzhanThe Yellow River basin is of critical strategic importance to China's economic and social development. The lower reaches are characterized by low flow rates and high sediment concentrations，exhibiting an uncoordinated water-sediment relationship.
Dongdong JIA +6 more
doaj +1 more source